Yersinia pestis v antigen Antibody (Va52): sc-52306

Yersinia pestis v antigen Antibody (Va52) is a mouse monoclonal IgG1 antibody that detects Yersinia pestis v antigen protein of Yersinia pestis origin by western blotting (WB) and enzyme-linked immunosorbent assay (ELISA). Anti-Yersinia pestis v antigen antibody (Va52) is available as a non-conjugated format. Yersinia pestis v antigen (Va52) antibody plays a crucial role in studying the bacterium′s virulence, as v antigen is involved in the translocation of Yersinia outer proteins (YOPs), which are essential for evading the host′s immune response. YOPs disrupt host cell signaling and promote bacterial survival by inhibiting phagocytosis, allowing Yersinia pestis to thrive within the host. Understanding v antigen function and interaction with YOPs is vital for developing targeted therapies and vaccines against infections caused by this pathogen. The plasmid-encoded virulence antigen is a major protective immunogen, highlighting its importance in the immune response to Yersinia pestis. Additionally, the transcriptional activator PhoP is essential for the bacterium′s survival in macrophage phagosomes, although the specific mechanisms by which PhoP enhances survival in these vacuoles remain to be fully elucidated.

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Yersinia pestis v antigen Antibody (Va52) References:

1. Small-molecule inhibition of siderophore biosynthesis in Mycobacterium tuberculosis and Yersinia pestis.  |  Ferreras, JA., et al. 2005. Nat Chem Biol. 1: 29-32. PMID: 16407990
2. Flagellin is an effective adjuvant for immunization against lethal respiratory challenge with Yersinia pestis.  |  Honko, AN., et al. 2006. Infect Immun. 74: 1113-20. PMID: 16428759
3. Virulence markers of LCR plasmid in Indian isolates of Yersinia pestis.  |  Khushiramani, R., et al. 2006. APMIS. 114: 15-22. PMID: 16499656
4. Yersinia outer-membrane protein B (YopB): a tool for identification of Yersinia pestis isolates.  |  Khushiramani, R., et al. 2006. J Med Microbiol. 55: 467-469. PMID: 16533997
5. Interaction of Yersinia pestis with macrophages: limitations in YopJ-dependent apoptosis.  |  Zauberman, A., et al. 2006. Infect Immun. 74: 3239-50. PMID: 16714551
6. Gamma interferon, tumor necrosis factor alpha, and nitric oxide synthase 2, key elements of cellular immunity, perform critical protective functions during humoral defense against lethal pulmonary Yersinia pestis infection.  |  Parent, MA., et al. 2006. Infect Immun. 74: 3381-6. PMID: 16714568
7. Efficient tracing of global isolates of Yersinia pestis by restriction fragment length polymorphism analysis using three insertion sequences as probes.  |  Torrea, G., et al. 2006. J Clin Microbiol. 44: 2084-92. PMID: 16757602
8. Characterization of phagosome trafficking and identification of PhoP-regulated genes important for survival of Yersinia pestis in macrophages.  |  Grabenstein, JP., et al. 2006. Infect Immun. 74: 3727-41. PMID: 16790745
9. Yersinia pestis YrbH is a multifunctional protein required for both 3-deoxy-D-manno-oct-2-ulosonic acid biosynthesis and biofilm formation.  |  Tan, L. and Darby, C. 2006. Mol Microbiol. 61: 861-70. PMID: 16817907

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Yersinia pestis v antigen Antibody (Va52) has 1 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Yersinia pestis v antigen Antibody (Va52) Specifications

Alternate Product Name: Yersinia pestis v antigen

Product Clone Name: Va52

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: Yersinia pestis v antigen

Epitope Species: Yersinia pestis

Product Reactivity/Detection: Yersinia pestis v antigen

Species Reactivity/Detection: Yersinia pestis

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for Yersinia pestis v antigen Antibody (Va52): N/A