Borrelia burgdorferi Osp A Antibody (0551): sc-58093

Borrelia burgdorferi Osp A Antibody (0551) is a mouse monoclonal IgG1 antibody that detects Borrelia burgdorferi Osp A protein by immunofluorescence (IF). Anti-Borrelia burgdorferi Osp A antibody (0551) is available as a non-conjugated format. The outer surface protein A (OspA) plays a crucial role in Lyme disease pathogenesis, being essential for spirochete adherence to host tissues and immune response evasion. OspA expression primarily occurs in tick vectors and remains critical for Borrelia burgdorferi survival during mammalian transmission. OspA facilitates initial host colonization, enabling bacterial infection establishment and systemic spread. Understanding OspA function remains vital for developing targeted therapies and vaccines against Lyme disease, representing a key factor in bacterial lifecycle and pathogenicity. Lyme disease, caused by Borrelia burgdorferi, is a vector-borne, multisystem inflammatory disease transmitted through Ixodes ricinus complex tick bites. Anti-Borrelia burgdorferi OspA antibody (0551) specificity makes this reagent valuable for studying Borrelia burgdorferi-host interactions and clinical Lyme disease diagnosis.

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Borrelia burgdorferi Osp A Antibody (0551) References:

1. In vitro susceptibility testing of four antibiotics against Borrelia burgdorferi: a comparison of results for the three genospecies Borrelia afzelii, Borrelia garinii, and Borrelia burgdorferi sensu stricto.  |  Sicklinger, M., et al. 2003. J Clin Microbiol. 41: 1791-3. PMID: 12682190
2. Characteristics of erythema migrans in Borrelia afzelii and Borrelia garinii infections.  |  Carlsson, SA., et al. 2003. Scand J Infect Dis. 35: 31-3. PMID: 12685881
3. Association of Borrelia garinii and B. valaisiana with songbirds in Slovakia.  |  Hanincová, K., et al. 2003. Appl Environ Microbiol. 69: 2825-30. PMID: 12732554
4. Effect of the salivary gland and midgut extracts from Ixodes ricinus and Dermacentor reticulatus (Acari: Ixodidae) on the growth of Borrelia garinii in vitro.  |  Rudolf, I. and Hubálek, Z. 2003. Folia Parasitol (Praha). 50: 159-60. PMID: 14560980
5. Ability of Ixodes persulcatus, Haemaphysalis concinna and Dermacentor silvarum ticks to acquire and transstadially transmit Borrelia garinii.  |  Sun, Y. and Xu, R. 2003. Exp Appl Acarol. 31: 151-60. PMID: 14756409
6. Comparative analysis of the Borrelia garinii genome.  |  Glöckner, G., et al. 2004. Nucleic Acids Res. 32: 6038-46. PMID: 15547252
7. Comparison of growth of Borrelia afzelii, B. garinii, and B. burgdorferi sensu stricto in MKP and BSK-II medium.  |  Ruzić-Sabljić, E. and Strle, F. 2004. Int J Med Microbiol. 294: 407-12. PMID: 15595391
8. Adhesion of Borrelia garinii to neuronal cells is mediated by the interaction of OspA with proteoglycans.  |  Rupprecht, TA., et al. 2006. J Neuroimmunol. 175: 5-11. PMID: 16603253
9. Enhanced culture of Borrelia garinii and Borrelia afzelii strains on a solid BSK-based medium in anaerobic conditions.  |  De Martino, SJ., et al. 2006. Res Microbiol. 157: 726-9. PMID: 16814991

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Borrelia burgdorferi Osp A Antibody (0551) has 4 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Borrelia burgdorferi Osp A Antibody (0551) Specifications

Alternate Product Name: OspA

Product Clone Name: 0551

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: Borrelia burgdorferi Osp A

Epitope Species: Borrelia burgdorferi

Product Reactivity/Detection: 28 kDa protein of Borrelia burgdorferi

Species Reactivity/Detection: Borrelia burgdorferi

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: IF

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for Borrelia burgdorferi Osp A Antibody (0551): N/A