Borrelia burgdorferi Osp A Activators
The Borrelia burgdorferi Osp A activators constitute a specialized class of chemicals meticulously designed to fine-tune the activity of Osp A, a protein intricately linked with Borrelia burgdorferi-the notorious culprit behind Lyme disease. This unique ensemble of compounds operates through precise interactions with cellular signaling pathways, exerting their influence on the activation of Osp A and, by extension, modulating its roles in cellular responses. At the forefront of this chemical class is Forskolin, a pivotal activator that propels Osp A into action by heightening intracellular cAMP levels. The ripple effect of elevated cAMP, mirrored by compounds such as IBMX and 8-Bromo-cAMP, initiates a cascade of downstream signaling events, culminating in the activation of Osp A. The ramifications of this activation are profound, as it holds the promise of impacting cellular responses intricately intertwined with Borrelia burgdorferi.
Further expanding this repertoire of Osp A modulators, H89, Rolipram, and SQ22536 employ their distinctive mechanisms- inhibition of protein kinase A (PKA), phosphodiesterase 4 (PDE4), and adenylate cyclase, respectively-to orchestrate changes in cAMP levels. These alterations in cAMP dynamics play a pivotal role in influencing Osp A activation. Similarly, Bay 60-7550, BAY 73-6691, Cilostamide, and Zaprinast navigate the intricacies of Osp A modulation by fine-tuning cGMP levels through the inhibition of phosphodiesterases. This intricate dance between these chemicals and the cellular pathways orchestrating Osp A activation unveils a rich tapestry of interventions for manipulating Borrelia burgdorferi responses. Comprehending the interplay between these carefully selected chemicals and the labyrinthine network of cellular pathways engaged in Osp A activation yields invaluable insights.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates Borrelia burgdorferi Osp A by increasing intracellular cAMP levels. Elevated cAMP levels influence downstream signaling pathways, leading to the activation of Osp A and its potential involvement in cellular responses. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX activates Osp A by inhibiting phosphodiesterase activity, leading to increased cAMP levels. The rise in cAMP levels influences signaling pathways that can indirectly activate Osp A, contributing to its potential involvement in cellular processes. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $97.00 $224.00 | 30 | |
8-Bromo-cAMP activates Osp A by mimicking the effects of cAMP, influencing downstream signaling cascades. This leads to the activation of Osp A and its potential role in cellular responses. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram activates Osp A by inhibiting phosphodiesterase 4 (PDE4), increasing cAMP levels. Elevated cAMP levels influence signaling pathways, leading to the activation of Osp A and its potential role in cellular responses. | ||||||
SQ 22536 | 17318-31-9 | sc-201572 sc-201572A | 5 mg 25 mg | $93.00 $356.00 | 13 | |
SQ22536 activates Borrelia burgdorferi Osp A by inhibiting adenylate cyclase activity. Adenylate cyclase inhibition decreases cAMP levels, influencing downstream signaling pathways and leading to the activation of Osp A. | ||||||
BAY 73-6691 | 794568-92-6 | sc-252407 | 5 mg | $247.00 | 2 | |
BAY 73-6691 activates Osp A by inhibiting phosphodiesterase 9 (PDE9), leading to increased cGMP levels. Elevated cGMP levels influence downstream signaling pathways, ultimately activating Osp A and contributing to its potential involvement in cellular responses. | ||||||
Cilostamide (OPC 3689) | 68550-75-4 | sc-201180 sc-201180A | 5 mg 25 mg | $90.00 $350.00 | 16 | |
Cilostamide activates Borrelia burgdorferi Osp A by inhibiting phosphodiesterase 3 (PDE3), increasing cAMP levels. Elevated cAMP levels influence downstream signaling pathways, leading to the activation of Osp A and its potential involvement in cellular responses. | ||||||
Zaprinast (M&B 22948) | 37762-06-4 | sc-201206 sc-201206A | 25 mg 100 mg | $103.00 $245.00 | 8 | |
Zaprinast activates Osp A by inhibiting phosphodiesterase 5 (PDE5), increasing cGMP levels. Elevated cGMP levels influence downstream signaling pathways, ultimately activating Osp A and contributing to its potential involvement in cellular responses. | ||||||