Molecular structure of SQ 22536, CAS Number: 17318-31-9
SQ 22536 (CAS 17318-31-9)
See product citations (13)
Alternate Names:
9-THF-Ade
Application:
SQ 22536 is an A cyclase inhibitor
CAS Number:
17318-31-9
Purity:
≥99%
Molecular Weight:
205.22
Molecular Formula:
C9H11N5O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
SQ 22536 is an A cyclase inhibitor that can permeate the cell. SQ 22536 can block cAMP enhancement mediated by Cordycepin (sc-203902), an inhibitor of human platelet aggregation. In platelet studies SQ 22536 was shown to reverse the antiplatelet effects of Sesamol (sc-253552) on p38 MAPK phosphorylation and platelet aggregation, and the stimulatory effects induced by Sesamol on VASP, eNOS phosphorylation, and NO release. SQ 22536 has demonstrated inhibition of the effect of glucagon on rat membrane cyclase activity and has reduced the effect of isoproterenol, epinephrine (sc-252779), norepinephrine, and phenylephrine. It functions as an enzyme inhibitor, an antioxidant, and possess anti-inflammatory properties.
SQ 22536 (CAS 17318-31-9) References
- Effects of SQ 22536, an adenylyl cyclase inhibitor, on isoproterenol-induced cyclic AMP elevation and relaxation in newborn ovine pulmonary veins. | Gao, Y. and Usha Raj, J. 2002. Eur J Pharmacol. 436: 227-33. PMID: 11858802
- Inhibition of adenylate cyclase of catfish and rat hepatocyte membranes by 9-(tetrahydro-2-furyl)adenine (SQ 22536). | Fabbri, E., et al. 1991. J Enzyme Inhib. 5: 87-98. PMID: 1669444
- Actions of vasopressin and isoprenaline on the ionic transport across the isolated frog skin in the presence and the absence of adenyl cyclase inhibitors MDL12330A and SQ22536. | Lippe, C. and Ardizzone, C. 1991. Comp Biochem Physiol C Comp Pharmacol Toxicol. 99: 209-11. PMID: 1711430
- Cordycepin (3'-deoxyadenosine) inhibits human platelet aggregation in a cyclic AMP- and cyclic GMP-dependent manner. | Cho, HJ., et al. 2007. Eur J Pharmacol. 558: 43-51. PMID: 17229422
- AQP1 gene expression is upregulated by arginine vasopressin and cyclic AMP agonists in trophoblast cells. | Belkacemi, L., et al. 2008. Life Sci. 82: 1272-80. PMID: 18538351
- Reversal of synaptic depression by serotonin at Aplysia sensory neuron synapses involves activation of adenylyl cyclase. | Goldsmith, BA. and Abrams, TW. 1991. Proc Natl Acad Sci U S A. 88: 9021-5. PMID: 1924365
- Potent antiplatelet activity of sesamol in an in vitro and in vivo model: pivotal roles of cyclic AMP and p38 mitogen-activated protein kinase. | Chang, CC., et al. 2010. J Nutr Biochem. 21: 1214-21. PMID: 20015631
- The possible roles of hyperpolarization-activated cyclic nucleotide channels in regulating pacemaker activity in colonic interstitial cells of Cajal. | Shahi, PK., et al. 2014. J Gastroenterol. 49: 1001-10. PMID: 23780559
- The adenylyl cyclase inhibitor MDL-12,330A potentiates insulin secretion via blockade of voltage-dependent K(+) channels in pancreatic beta cells. | Li, X., et al. 2013. PLoS One. 8: e77934. PMID: 24205033
- Adenylate cyclase system is essential for long-term facilitation at the crayfish neuromuscular junction. | Dixon, D. and Atwood, HL. 1989. J Neurosci. 9: 4246-52. PMID: 2480401
- Muscarinic receptor control of pyramidal neuron membrane potential in the medial prefrontal cortex (mPFC) in rats. | Kurowski, P., et al. 2015. Neuroscience. 303: 474-88. PMID: 26186898
- Pituitary Adenylate Cyclase-activating Polypeptide Inhibits Pacemaker Activity of Colonic Interstitial Cells of Cajal. | Wu, MJ., et al. 2015. Korean J Physiol Pharmacol. 19: 435-40. PMID: 26330756
- Calcitonin gene-related peptide mediates an inflammatory response in Schwann cells via cAMP-dependent ERK signaling cascade. | Permpoonputtana, K., et al. 2016. Life Sci. 144: 19-25. PMID: 26596264
- Exenatide exerts direct protective effects on endothelial cells through the AMPK/Akt/eNOS pathway in a GLP-1 receptor-dependent manner. | Wei, R., et al. 2016. Am J Physiol Endocrinol Metab. 310: E947-57. PMID: 27072494
- SQ 22536, an adenylate-cyclase inhibitor, prevents the antiplatelet effect of dazoxiben, a thromboxane-synthetase inhibitor. | Bertelé, V., et al. 1984. Thromb Haemost. 51: 125-8. PMID: 6326343
Inhibitor of:
A cyclase, A1Up, ADX, AKAP 2, AKAP 220, C2orf77, cAMP, cAMP-GEFII, Cdc35, CNBD2, D830046C22Rik, EG433107, EG436049, EG546488, Gα 14, Gα s, GPR family (GPCR;G protein-coupled), GPR115, GPR123, GPR128, GPR139, GPR178, Heat shock protein family A (Hsp70), HM74A, Lipocalin-14, MTH1, Neuropeptide S, Olfr1036, Olfr1043, Olfr108, Olfr1086, Olfr1178, Olfr373, Olfr441, Olfr49, Olfr490, Olfr491, Olfr492, Olfr51, Olfr612, Olfr701, Olfr702, Olfr703, Olfr704, Olfr705, Olfr706, Olfr707, Olfr708, Olfr716, Olfr734, Olfr76, Olfr761, Olfr763, Olfr779, Olfr871, Olfr872, Olfr874, Olfr876, Olfr877, Olfr878, Olfr890, Olfr891, Olfr893, Olfr894, Olfr895, Olfr898, Olfr899, Olfr904, Olfr905, Olfr906, Olfr992, OPN1MW2, OR10H1, OR5B3, PKA IIβ reg, PKAα cat, Protein Kinase A (PRKAR1A PRKAR1B), RAPGEFL1, RGS22, SC, Vmn1r139, Vmn1r163, Vmn2r22, and VPAC2.Activator of:
AI314180, ALG-4, ANGEL2, APOBEC4, BAALC, BCNP1, Borrelia burgdorferi Osp A, CD39L3, CMV gH, CRLR, DPPA2, EG546488, EG546901, GALR1, GIPR, Glutamine-rich 2, GPR144, GPR8, HuC, INPP1, KLHL12, KLHL34, LANCL2, Latrophilin-2, LMO3, LTH-A, MACROD2, MC2-R, MPP3, nardilysin, NICE4, Olfr544, Olr22, OR51M1, ORNT1, ORNT2, Pax-4, PDE6D, PKAγ cat, PTG, Rap 1A, SPRED2, TFEB, TINP1, and Vmn1r173.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SQ 22536, 5 mg | sc-201572 | 5 mg | $93.00 | |||
SQ 22536, 25 mg | sc-201572A | 25 mg | $356.00 |