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Investigator Awards

The Santa Cruz Biotechnology
INVESTIGATOR AWARD
recognizes excellence
in research.

Santa Cruz Biotechnology purple scientific research investigator award badge.

Submitted papers are
reviewed to assess:

Scientific Significance
Scientific Impact
Experiment Design
Publication Integrity and Quality

One winner is chosen each year in January and will be selected from papers published within the previous year.

How to Apply:

Submit your accepted paper (1st author) referencing the use of any Santa Cruz Biotechnology product.
Submit a product review for one or more products used in the paper.

SUBMIT ENTRY

Awards

The winner receives 5000 Santa Cruz Biotechnology Cruz Credits^TM, which can be applied towards future product purchases or special promotions.
All entrants receive 375 Santa Cruz Biotechnology Cruz Credits^TM (USD equivalent); learn more about Cruz Credits^TM.

JANUARY 2025 Santa Cruz Biotechnology Investigator Award Recipient

CONGRATULATIONS,
Alison K Barrett!

Alison K Barrett is the first author selection from 120 applicants for nomination to receive the January 2025 Investigator Award:

Alison K Barrett 1 , Manisha R Shingare 1 , Andreas Rechtsteiner 2 , Kelsie M Rodriguez 1 , Quynh N Le 1 , Tilini U Wijeratne 1 , Corbin E Mitchell 1 , Miles W Membreno 1 , Seth M Rubin 3 , Gerd A Müller 4. HDAC activity is dispensable for repression of cell-cycle genes by DREAM and E2F:RB complexes. PMID: 38789411. https://pubmed.ncbi.nlm.nih.gov/38789411/

Abstract

Histone deacetylases (HDACs) play a crucial role in transcriptional regulation and are implicated in various diseases, including cancer. They are involved in histone tail deacetylation and canonically linked to transcriptional repression. Previous studies suggested that HDAC recruitment to cell-cycle gene promoters via the retinoblastoma (RB) protein or the DREAM complex through SIN3B is essential for G1/S and G2/M gene repression during cell-cycle arrest and exit. Here we investigate the interplay among DREAM, RB, SIN3 proteins, and HDACs in the context of cell-cycle gene repression. Knockout of SIN3B does not globally derepress cell-cycle genes in non-proliferating HCT116 and C2C12 cells. Loss of SIN3A/B moderately upregulates several cell-cycle genes in HCT116 cells but does so independently of DREAM/RB. HDAC inhibition does not induce general upregulation of RB/DREAM target genes in arrested transformed or non-transformed cells. Our findings suggest that E2F:RB and DREAM complexes can repress cell-cycle genes without relying on HDAC activity.

Previous SCBT Investigator Award Winners

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JANUARY 2024 Ariane Schleinitz	Ariane Schleinitz1, Lara-Alina Pöttgen1, Tal Keren-Kaplan2, Jing Pu3, Paul Saftig4, Juan S. Bonifacino2, Albert Haas1,*, Andreas Jeschke. Consecutive functions of small GTPases guide HOPS-mediated tethering of late endosomes and lysosomes. PMID: 36640308. https://pubmed.ncbi.nlm.nih.gov/36640308/
JANUARY 2023 Giulia Angelini	Giulia Angelini, Lidia Castagneto-Gissey, Serenella Salinari, Alessandro Bertuzzi, Danila Anello, Meenakshi Pradhan, Marlen Zschätzsch , Paul Ritter, Carel W Le Roux, Francesco Rubino, Nicola Basso, Giovanni Casella, Stefan R Bornstein, Valentina Tremaroli , Geltrude Mingrone. Upper gut heat shock proteins HSP70 and GRP78 promote insulin resistance, hyperglycemia, and non-alcoholic steatohepatitis. Nature Communications. 2022 December 13(1):7715. doi: 10.1038/s41467-022-35310-5. PMID: 36513656
JANUARY 2022 José M Navarro-Pando	José M. Navarro-Pando, Elísabet Alcocer-Gómez, Beatriz Castejón-Vega, Elena Navarro-Villarán, Mónica Condés-Hervás, María Mundi-Roldan, Jordi Muntané, Antonio J. Pérez-Pulido, Pedro Bullon, Chun Wang, Hal M. Hoffman, Alberto Sanz, Gabriel Mbalaviele, Bernhard Ryffel, Mario D. Cordero. Inhibition of the NLRP3 inflammasome prevents ovarian aging. Science Advances 2021 January 1;7(1):eabc7409. PMID: 33523841.
JANUARY 2021 Wei Li	Wei Li, Jing Hu, Bi Shi, Francesco Palomba, Michelle A. Digman, Enrico Gratton & Hao Jiang: Biophysical properties of AKAP95 protein condensates regulate splicing and tumorigenesis. Nature Cell Biology. 2020. 22:960–972. PMID: 32719551
JANUARY 2020 Maiwen Caudron-Herger	Caudron-Herger M, Rusin SF, Adamo ME, Seiler J, Schmid VK, Barreau E, Kettenbach AN, Diederichs S. R-DeeP: Proteome-wide and Quantitative. Identification of RNA-Dependent Proteins by Density Gradient Ultracentrifugation. Mol Cell. 2019 Jul 11;75(1):184-199. PMID: 31076284
JANUARY 2019 Sanjay Awasthi	Awasthi S, Tompkins J, Singhal J, Riggs AD, Yadav S, Wu X, Singh S, Warden C, Liu Z, Wang J, Slavin TP, Weitzel JN, Yuan YC, Awasthi M, Srivastava SK, Awasthi YC, Singhal SS. Rlip depletion prevents spontaneous neoplasia in TP53 null mice. Proc Natl Acad Sci U S A. 2018 Apr 10;115(15):3918-3923. doi: 10.1073/pnas.1719586115. Epub 2018 Mar 23. PubMed PMID: 29572430; PubMed Central PMCID: PMC5899455.
JANUARY 2018 Li Jiang	Jiang L, Shao C, Wu QJ, Chen G, Zhou J, Yang B, Li H, Gou LT, Zhang Y, Wang Y, Yeo GW, Zhou Y, Fu XD. NEAT1 scaffolds RNA-binding proteins and the Microprocessor to globally enhance pri-miRNA processing. Nat Struct Mol Biol. 2017 Oct;24(10):816-824. doi: 10.1038/nsmb.3455. Epub 2017 Aug 28. PubMed PMID: 28846091.
JANUARY 2017 Marta N. Shahbazi	Shahbazi MN, Jedrusik A, Vuoristo S, Recher G, Hupalowska A, Bolton V, Fogarty NM, Campbell A, Devito LG, Ilic D, Khalaf Y, Niakan KK, Fishel S, Zernicka-Goetz M. Self-organization of the human embryo in the absence of maternal tissues. Nat Cell Biol. 2016 Jun;18(6):700-8. PubMed PMID: 27144686
JANUARY 2016 Nesrine Abboud	Abboud N, Moore-Morris T, Hiriart E, Yang H, Bezerra H, Gualazzi MG, Stefanovic S, Guénantin AC, Evans SM, Pucéat M. A cohesin-OCT4 complex mediates Sox enhancers to prime an early embryonic lineage. Nat Commun. 2015 Apr 8;6:6749. PMID: 25851587
JULY 2015 Tobias Wagner	Wagner T, Kiweler N, Wolff K, Knauer SK, Brandl A, Hemmerich P, Dannenberg JH, Heinzel T, Schneider G, Krämer OH. Sumoylation of HDAC2 promotes NF-κB-dependent gene expression. Oncotarget. 2015 Mar 30;6(9):7123-35. PubMed PMID: 25704882; PubMed Central PMCID: PMC4466673.
JANUARY 2015 Norman Ertych	Ertych N, Stolz A, Stenzinger A, Weichert W, Kaulfuß S, Burfeind P, Aigner A, Wordeman L, Bastians H. Increased microtubule assembly rates influence chromosomal instability in colorectal cancer cells. Nat Cell Biol. 2014 Aug;16(8):779-91. PubMed PMID: 24976383.
JULY 2014 Michelino Di Rosa	Di Rosa M, Tibullo D, Vecchio M, Nunnari G, Saccone S, Di Raimondo F, Malaguarnera L. Determination of chitinases family during osteoclastogenesis. Bone. 2014 Apr;61:55-63.PMID: 24440516.
JANUARY 2014 Daniel Martinez Molina	Daniel Martinez Molina, Rozbeh Jafari, Marina Ignatushchenko, Takahiro Seki, E. Andreas Larsson, Chen Dan, Lekshmy Sreekumar, Yihai Cao, PaÌˆr Nordlund. Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay. Science. 2013 July 5;341(6141):84-87. PMID: 23828940
JULY 2013 Simona Morone	Morone S, Lo-Buono N, Parrotta R, Giacomino A, Nacci G, Brusco A, Larionov A, Ostano P, Mello-Grand M, Chiorino G, Ortolan E, Funaro A. Overexpression of CD157 contributes to epithelial ovarian cancer progression by promoting mesenchymal differentiation. PLoS One. 2012;7(8):e43649. PMID: 22916288
JANUARY 2013 Pol Margalef	Margalef P, Fernández-Majada V, Villanueva A, Garcia-Carbonell R, Iglesias M, López L, Martínez-Iniesta .M, Villà-Freixa J, Mulero MC, Andreu M, Torres F, Mayo MW, Bigas A, Espinosa L. A Truncated Form of IKKα Is Responsible for Specific Nuclear IKK Activity in Colorectal Cancer. Cell Reports. 2012 October 25; 2(4):840-854. PMID: 23041317
JULY 2012 Maria Rosaria Amoroso	Amoroso MR, Matassa DS, Laudiero G, Egorova AV, Polishchuk RS, Maddalena F, Piscazzi A, Paladino S, Sarnataro D, Garbi C, Landriscina M, Esposito F. TRAP1 and the proteasome regulatory particle TBP7/Rpt3 interact in the endoplasmic reticulum and control cellular ubiquitination of specific mitochondrial proteins. Cell Death Differ. 2012 19(4):592-604. PMID 21979464.
JANUARY 2012 Bilal Hafeez	Bilal Bin Hafeez, Weixiong Zhong, Jamey Weichert, Nancy E. Dreckschmidt, Mohammad Sarwar Jamal, Ajit K. Verma. Genetic ablation of PKC epsilon inhibits prostate cancer development and metastasis in transgenic mouse model of prostate adenocarcinoma. Cancer Res. 2011 71(6):2318-2327. PMID 21406403.
JULY 2011 Chih-Hsin Tang	Chih-Hsin Tang, Cheng-Fong Chen, Wei-Ming Chen, Yi-Chin Fong. IL-6 Increases MMP-13 Expression and Motility in Human Chondrosarcoma Cells. J Biol Chem. 2011 286(13):11056-66. PMID: 21278254
JANUARY 2011 Prerna Kumar	Prerna Kumar, Renu Garg, Gevoni Bolden, Kailash N. Pandey. Interactive roles of Ets-1, Sp1, and acetylated histones in the retinoic acid-dependent activation of guanylyl cyclase/atrial natriuretic peptide receptor-A gene transcription. J Biol Chem. 2010 285(48):37521-37530. PMID: 20864529
JULY 2010 Barbara Bellei	Barbara Bellei, Vittoria Maresca, Enrica Flori, Angela Pitisci, Lionel Larue, Mauro Picardo. p38 regulates pigmentation via proteasomal degradation of tyrosinase. J Biol Chem. 2010 Mar 5;285(10):7288-99. PMID 20053998
JANUARY 2010 Pan-Yue Deng	Pan-Yue Deng, Zhaoyang Xiao, Chuanxiu Yang, Lalida Rojanathammanee, Laurel Grisanti, John Watt, Jonathan D. Geiger, Rugao Liu, James E. Porter and Saobo Lei. GABA_B Receptor Activation Inhibits Neuronal Excitability and Spatial Learning in the Entorhinal Cortex by Activating TREK-2 K⁺ Channels. Neuron 2009 63(2):230-243. PMID: 19640481
JULY 2009 Richard Tomasini	Richard Tomasini, Katsuya Tsuchihara, Chiharu Tsuda, Suzanne K. Lau, Margareta Wilhelm, Alessandro Ruffini, Ming-sound Tsao, Juan L. Iovanna, Andrea Jurisicova, Gerry Melino, and Tak W. Mak. TAp73 regulates the spindle assembly checkpoint by modulating BubR1 activity. Proc Natl Acad Sci U S A. 2009 106(3):797-802. PMID: 19139399
JANUARY 2009 Ning Ding	Ning Ding, Haiying Zhou, Pierre-Olivier Esteve, Hang Gyeong Chin, Seokjoong Kim, Xuan Xu, Sumy M. Joseph, Michael J. Friez, Charles E. Schwartz, Sriharsa Pradhan and Thomas G. Boyer. Mediator links epigenetic silencing of neuronal gene expression with x-linked mental retardation. Molecular Cell. 2008 31:347-359. PMID: 18691967
JULY 2008 Melissa R. Junttila	Junttila MR, Puustinen P, Niemelä M, Ahola R, Arnold H, Böttzauw T, Ala-aho R, Nielsen C, Ivaska J, Taya Y, Lu SL, Lin S, Chan EK, Wang XJ, Grènman R, Kast J, Kallunki T, Sears R, Kähäri VM, Westermarck J. CIP2A inhibits PP2A in human malignancies. Cell. 2007 Jul 13;130(1):51-62. PMID: 17632056
JANUARY 2008 Kwang Seok Ahn	Ahn, K.S., Sethi, G., Krishnan, K. and Aggarwal, B.B. Gamma-tocotrienol inhibits nuclear factor-kappaB signaling pathway through inhibition of receptor-interacting protein and TAK1 leading to suppression of antiapoptotic gene products and potentiation of apoptosis. 2007. J. Biol. Chem. 282:809-820. PMID: 17114179
JULY 2007 Young-Gun Yoo	Yoo, Y.G., Na, T.Y., Yang, W.K., Kim, H.J., Lee, I.K., Kong, G., Chung, J.H. and Lee, M.O. 2006. 6-Mercaptopurine, an activator of Nur77, enhances transcriptional activity of HIF-1alpha resulting in new vessel formation. Oncogene 26: 3823-3834.
JANUARY 2007 Ayyakkannu Ayyanan	Ayyanan A, Civenni G, Ciarloni L, Morel C, Mueller N, Lefort K, Mandinova A, Raffoul W, Fiche M, Dotto GP, Brisken C. Increased Wnt signaling triggers oncogenic conversion of human breast epithelial cells by a Notch-depedent mechanism. Proc. Natl. Acad. Sci. USA. 2006. 103:3799-3804.
JULY 2006 Vadim Budagian	Budagian V, Bulanova E, Orinska Z, Thon L, Mamat U, Bellosta P, Basilico C, Adam D, Paus R, Bulfone-Paus S. A promiscuous liaison between IL-15 receptor and Axl receptor tyrosine kinase in cell death control. EMBO J. 2005 Dec 21;24(24):4260-70. Epub 2005 Nov 24.
JANUARY 2006 Irina Kratchmarova	Irina Kratchmarova, Blagoy Blagoev, Mandana Haack-Sorensen, Moustapha Kassem, Matthias Mann1. Mechanism of Divergent Growth Factor Effects in Mesenchymal Stem Cell Differentiation. Science. 2005 Jun 3; 308(5727):1472-7.
JULY 2005 Maen Abdeirahim	Abdelrahim, M., Lui, S., and Safe, S. 2005. Induction of Endoplasmic Reticulum (ER)-Induced Stress Genes in Panc-1 Pancreatic Cancer Cells is Dependent on Sp Proteins. J Biol Chem. 280(16):16508-13
JANUARY 2005 J. L. Lavrrar	Lavrrar JL and Farnham PJ. 2004. The use of transient chromatin immunoprecipitation assays to test models for E2F1-specific transcriptional activation. J Biol. Chem. 2004 279:46343-46349.
JULY 2004 Masako Miura	Miura, M., Gronthos, S., Zhao, M., Lu, B., Fisher, LW., Robey, PG., and Shi, S. 2003. SHED: stem cells from human exfoliated deciduous teeth. PNAS USA. 100(10):5807-5812
JANUARY 2004 Sarah P. Thayer	Sarah P. Thayer, Pasca di Magliano, P., Heiser, P., Nielson, C., Roberts, D., Lauwers, G., Qi, Y., Gysin, S., Fernndez-del Castillo, C., Yajnik, V., Antoniu, B., McMahon, M., Warshaw, A., and Hebrok, M. 2003. Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis. Nature. 425:851-856
JULY 2003 Marina Macias-Silva	Marina Macias-Silva, Li, W., Leu, L.I., Crissey, S. M.A., and Taub, R. 2002. Up-regulated transcriptional repressors SnoN and Ski Bind Smad proteins to antagonize transforming growth factor- signals during liver regeneration. J. Biol. Chem. 277: 28483-28490.
JANUARY 2003 Nigel Carter	Carter, N., Nakamoto, T., Hirai, H., and Hunter, T. 2002. EphrinA1-induced cytoskeletal re-organization requires FAK and p130(cas). Nat. Cell Biol. 4: 565-573.
JULY 2002 A.S. Weinmann	Weinmann, A.S., Bartley, S.M., Zhang, T., Zhang, .MQ., and Farnham, P.J. 2001. Use of chromatin immunoprecipitation to clone novel E2F target promoters. Mol. Cell. Biol. 21: 6820-6832.
JANUARY 2002 Olivier Nicole	Olivier Nicole, Fabian Docagne, Carine Ali, Isabelle Margaill, Peter Carmeliet, Eric T. MacKenzie, Denis Vivien and Alain Buisson. 2001. The proteolytic activity of tissue-plasminogen activator enhances NMDA receptor-mediated signaling. Nature Medicine. 7: 59-64.
JULY 2001 Yan-Hong Zhang	Yan-Hong Zhang, Antoinette Heulsmann, M. Mehrdad Tondravi, Aditi Mukherjee, and Yousef Abu-Amer. 2001. Tumor Necrosis Factor- (TNF) Stimulates RANKL-induced Osteoclastogenesis via Coupling of TNF Type 1 Receptor and RANK Signaling Pathways. J. Biol. Chem. 276: 563-568.
JANUARY 2001 Giulia Guarguaglini	Giulia Guarguaglini, Luigina Renzi, Filippo D'Ottavio, Barbara Di Fiore, Martina Casenghi, Enrico Cundari, and Patrizia Lavia. 2000. Regulated Ran-binding Protein 1 Activity Is Required for Organization and Function of the Mitotic Spindle in Mammalian Cells in Vivo. Cell Growth & Differentiation Vol. 11: 455-465
JULY 2000 Hui Miao	Hui Miao, Elisabeth Burnett, Michael Kinch, Erin Simon, and Bingcheng Wang. 2000. Activation of EphA2 kinase suppresses integrin function and causes focal-adhesion-kinase dephosphorylation. Nature Cell Biology 2: 62-69.
JANUARY 2000 Hongwu Chen	Hongwu Chen, Richard J. Lin, Wen Xie, Damien Wilpitz, and Ronald M. Evans. 1999. Regulation of Hormone-Induced Hyperacetylation and Gene Activation via Acetylation of an Acetylase. Cell 98: 675-686.
JULY 1999 Jan Karlseder	Jan Karlseder, Dominique Broccoli, Yumin Dai, Stephen Hardy and Titia de Lange. 1999. p53- and ATM-Dependent Apoptosis Induced by Telomeres Lacking TRF2. Science 283: 1321-1325.
JANUARY 1999 Shoji Yamaoka	Shoji Yamaoka, Gilles Courtois, Christine Bessia, Simon T. Whiteside, Robert Weil, Fabrice Agou, Heather E. Kirk, Robert J. Kay, and Alain Isral. 1998. Complementation Cloning of NEMO, a Component of the IB Kinase Complex Essential for NF-B ActivationK. Cell 93: 1231-1240.
JULY 1998 Robin X. Luo	Robin X. Luo, Antonio A. Postigo, and Douglas C. Dean. 1998. Rb Interacts with Histone Deacetylase to Repress Transcription. Cell 92: 463-473.
JANUARY 1998 Catherine H. Regnier	Catherine H. Regnier, Ho Yeong Song, Xiong Gao, David V. Goeddel, Zhaodan Cao, and Mike Rothe. 1997. Identification and Characterization of an IB Kinase. Cell 90: 373-383.
JULY 1997 Frank S. Lee	Jeremiah Hagler, Zhigian J. Chen, and Tom Maniatis. 1997. Activation of the IB Kinase Complex by MEKK1, a Kinase of the JNK Pathway. Cell 88: 213-222.
JANUARY 1997 Daniel J. Van Antwerp	Daniel J. Van Antwerp, Seamus J. Martin, Tal Kafri, Douglas R. Green and Inder M. Verma. 1996. Suppression of TNF--induced apoptosis by NF-B. Science 274: 787-789.
JULY 1996 Shuqian Jing	Shuqian Jing, Duanzhi Wen, Yanbin Yu, Paige L. Holst, Yi Luo, Mei Fang, Rami Tamir, Laarni Antonio, Zheng Hu, Rod Cupples, Jean-Claude Louis, Sylvia Hu, Bruce W. Altrock and Gary M. Fox. 1996. GDNF-induced activation of the Ret protein tyrosine kinase is mediated by GDNFR-, a novel receptor for GDNF. Cell 85: 1113-1124.
JANUARY 1996 Omar A. Coso	Omar A. Coso, Mario Chiariello, Jin-Chen Yu, Hidemi Teramoto, Piero Crespo, Ningzhi Xu, Toru Miki, and J. Silvio Gutkind. 1995. The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway. Cell 81: 1137-1146.
JULY 1995 David D. Schlaepfer	David D. Schlaepfer, Steven K. Hanks, Tony Hunter, and Peter van der Geer. 1994. Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase. Nature 372: 786-791
JANUARY 1995 Ellen Freed	Ellen Freed, Marc Symons, Susan G. Macdonald, Frank McCormick, and Rosamaria Ruggieri. 1994. Binding of 14-3-3 proteins to the protein kinase Raf and effects on its activation. Science 265: 1713-1716.

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Investigator Awards

Submitted papers are reviewed to assess:

How to Apply:

Awards

JANUARY 2025 Santa Cruz Biotechnology Investigator Award Recipient

Abstract

Previous SCBT Investigator Award Winners

JANUARY 2024

Ariane Schleinitz

JANUARY 2023

Giulia Angelini

JANUARY 2022

José M Navarro-Pando

JANUARY 2021

Wei Li

JANUARY 2020

Maiwen Caudron-Herger

JANUARY 2019

Sanjay Awasthi

JANUARY 2018

Li Jiang

JANUARY 2017

Marta N. Shahbazi

JANUARY 2016

Nesrine Abboud

JULY 2015

Tobias Wagner

JANUARY 2015

Norman Ertych

JULY 2014

Michelino Di Rosa

JANUARY 2014

Daniel Martinez Molina

JULY 2013

Simona Morone

JANUARY 2013

Pol Margalef

JULY 2012

Maria Rosaria Amoroso

JANUARY 2012

Bilal Hafeez

JULY 2011

Chih-Hsin Tang

JANUARY 2011

Prerna Kumar

JULY 2010

Barbara Bellei

JANUARY 2010

Pan-Yue Deng

JULY 2009

Richard Tomasini

JANUARY 2009

Ning Ding

JULY 2008

Melissa R. Junttila

JANUARY 2008

Kwang Seok Ahn

JULY 2007

Young-Gun Yoo

JANUARY 2007

Ayyakkannu Ayyanan

JULY 2006

Vadim Budagian

JANUARY 2006

Irina Kratchmarova

JULY 2005

Maen Abdeirahim

JANUARY 2005

J. L. Lavrrar

JULY 2004

Masako Miura

JANUARY 2004

Sarah P. Thayer

JULY 2003

Marina Macias-Silva

JANUARY 2003

Nigel Carter

JULY 2002

A.S. Weinmann

JANUARY 2002

Submitted papers are
reviewed to assess: