HSP 65 Antibody (BDI577): sc-57842
- HSP 65 Antibody (BDI577) is a mouse monoclonal IgG2a provided at 100 µg/ml
- raised against purified HSP 65 of Mycobacterium tuberculosis origin
- recommended for detection of HSP 65 of Mycobacterium tuberculosis origin by WB; non cross-reactive with M. bovis, M. avium, M. phlei, M. parafortuitum, Rhodococcus species, B. subtilis, S. pneumoniae or E. coli
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for HSP 65 Antibody (BDI577). This work is in progress.
HSP 65 Antibody (BDI577) is a mouse monoclonal IgG2a antibody that detects HSP 65 in Mycobacterium tuberculosis by western blotting (WB). HSP 65, a member of the heat shock protein family, plays a crucial role in proper protein folding and assembly within cells, which maintains cellular homeostasis and stress response. HSP 65 primarily functions in mitochondria, assisting with newly synthesized polypeptide folding and denatured protein refolding to prevent aggregation and ensure proper cellular function. HSP 65′s mitochondrial presence supports mitochondrial biogenesis and function, critical for energy production and metabolic regulation. HSP 65 (BDI577) monoclonal antibody helps researchers investigate immune responses, particularly T cell activation, making HSP 65 significant for infectious disease and autoimmune condition studies. Anti-HSP 65 antibody (BDI577) serves as a valuable research tool for studying HSP 65′s role in Mycobacterium tuberculosis and disease processes.
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HSP 65 Antibody (BDI577) References:
- Immunization of low-density lipoprotein receptor deficient (LDL-RD) mice with heat shock protein 65 (HSP-65) promotes early atherosclerosis. | Afek, A., et al. 2000. J Autoimmun. 14: 115-21. PMID: 10677242
- Expression of HSP-65 in jejunal epithelial cells in patients clinically suspected of coeliac disease. | Iltanen, S., et al. 1999. Autoimmunity. 31: 125-32. PMID: 10680751
- T cell reactivity to an epitope of the mycobacterial 65-kDa heat-shock protein (hsp 65) corresponds with arthritis susceptibility in rats and is regulated by hsp 65-specific cellular responses. | Hogervorst, EJ., et al. 1991. Eur J Immunol. 21: 1289-96. PMID: 1709871
- Possible significance of anti-heat shock protein (HSP-65) antibodies in autoimmune myasthenia gravis. | Patil, SA., et al. 2013. J Neuroimmunol. 257: 107-9. PMID: 23466130
- Behçet Disease serum is immunoreactive to neurofilament medium which share common epitopes to bacterial HSP-65, a putative trigger. | Lule, S., et al. 2017. J Autoimmun. 84: 87-96. PMID: 28844827
- Amplification of Hsp 65 gene and usage of restriction endonuclease for identification of non tuberculous rapid grower mycobacterium. | Verma, AK., et al. 2018. Indian J Tuberc. 65: 57-62. PMID: 29332650
- Novel and rare species of nontuberculous mycobacteria by Hsp-65 gene sequencing. | Kadasu, R., et al. 2022. Int J Mycobacteriol. 11: 423-428. PMID: 36510929
- Humoral response to hsp 65 in multiple sclerosis and other neurologic conditions. | Gao, YL., et al. 1994. Neurology. 44: 941-6. PMID: 8190301
- Immunoblot studies in the differential diagnosis of porcine brucellosis: an immunodominant 62 kDa protein is related to the mycobacterial 65 kDa heat shock protein (HSP-65). | Spencer, SA., et al. 1994. Vet Microbiol. 39: 47-60. PMID: 8203127
- HSP-derived peptides inducing uveitis and IgG and IgA antibodies. | Uchio, E., et al. 1998. Exp Eye Res. 67: 719-27. PMID: 9990336
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HSP 65 Antibody (BDI577) | sc-57842 | 100 µg/ml | $316.00 |