BoNT/A Antibody (KBA211): sc-51774

BoNT/A Antibody (KBA211) is a mouse monoclonal IgG1 antibody that detects BoNT/A protein of Clostridium botulinum origin by enzyme-linked immunosorbent assay (ELISA). Anti-BoNT/A antibody (KBA211) is available as the non-conjugated format. Botulinum neurotoxin type A, commonly referred to as BoNT/A, is one of the most potent neurotoxins known, with a mechanism of action critical for understanding both pathogenicity and therapeutic applications. BoNT/A functions as a zinc-dependent endopeptidase that specifically cleaves SNAP-25, a vital protein in the synaptic vesicle release process. By disrupting the exocytotic machinery, BoNT/A effectively inhibits acetylcholine release, leading to flaccid paralysis, which is the hallmark of botulism. The dimeric structure of BoNT/A in aqueous solution is essential for stability and activity, allowing maintenance of toxic effects while being harnessed for therapeutic purposes, such as treating muscle spasms and chronic pain. BoNT/A′s ability to modulate neurotransmitter release has made BoNT/A (KBA211) monoclonal antibody valuable for studying neurotoxin-target interactions.

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BoNT/A Antibody (KBA211) References:

1. Development of vaccines for prevention of botulism.  |  Byrne, MP. and Smith, LA. 2000. Biochimie. 82: 955-66. PMID: 11086225
2. Light chain of botulinum A neurotoxin expressed as an inclusion body from a synthetic gene is catalytically and functionally active.  |  Ahmed, SA. and Smith, LA. 2000. J Protein Chem. 19: 475-87. PMID: 11195972
3. Type A botulinum toxin for the treatment of hypertrophy of the masseter and temporal muscles: an alternative treatment.  |  von Lindern, JJ., et al. 2001. Plast Reconstr Surg. 107: 327-32. PMID: 11214045
4. The role of the synaptic protein snap-25 in the potency of botulinum neurotoxin type A.  |  Keller, JE. and Neale, EA. 2001. J Biol Chem. 276: 13476-82. PMID: 11278807
5. A correlation between differential structural features and the degree of endopeptidase activity of type A botulinum neurotoxin in aqueous solution.  |  Cai, S. and Singh, BR. 2001. Biochemistry. 40: 4693-702. PMID: 11294637
6. [Reduction of pain and muscle spasms by botulinum toxin A].  |  Kelm, S., et al. 2001. Nervenarzt. 72: 302-6. PMID: 11320866
7. A novel neurotoxoid vaccine prevents mucosal botulism.  |  Kobayashi, R., et al. 2005. J Immunol. 174: 2190-5. PMID: 15699151

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-BoNT/A Antibody (KBA211) has 0 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

BoNT/A Antibody (KBA211) Specifications

Alternate Product Name: BoNT/A

Product Clone Name: KBA211

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: BoNT/A

Epitope Species: Clostridium botulinum

Product Reactivity/Detection: BoNT/A

Species Reactivity/Detection: Clostridium botulinum

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: ELISA

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for BoNT/A Antibody (KBA211): N/A