Choleragenoid Antibody (3D11): sc-51838

Choleragenoid Antibody (3D11) is a mouse monoclonal IgG1 antibody that detects Choleragenoid in mouse, rat, and human samples through enzyme-linked immunosorbent assay (ELISA). Choleragenoid, also known as the B subunit of cholera toxin, plays a crucial role in cholera pathogenesis by binding to GM1-ganglioside receptors on intestinal epithelial cell surfaces. This binding facilitates the delivery of the enzymatic A subunit into cells, triggering a cascade of events leading to adenylate cyclase activation. The subsequent increase in intracellular cyclic adenosine monophosphate (cAMP) levels results in electrolyte and water secretion into the intestinal lumen, causing severe diarrhea characteristic of cholera infection. Understanding Choleragenoid function is vital for developing therapeutic strategies and vaccines against cholera, as anti-Choleragenoid antibody (3D11) highlights the mechanisms of toxin disruption of normal cellular processes and disease contribution. Choleragenoid monoclonal antibody (3D11) serves as an invaluable tool for researchers studying cholera toxin interactions and cellular signaling pathways.

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Choleragenoid Antibody (3D11) References:

1. Peripheral nerve lesion-induced uptake and transport of choleragenoid by capsaicin-sensitive c-fibre spinal ganglion neurons.  |  Jancsó, G., et al. 2002. Acta Biol Hung. 53: 77-84. PMID: 12064782
2. WGA-HRP and choleragenoid-HRP as anterogradely transported tracers in vagal visceral afferents and binding of WGA and choleragenoid to nodose ganglion neurons in rodents.  |  Robertson, B., et al. 1992. Brain Res. 590: 207-12. PMID: 1384931
3. Central projections of the sciatic, saphenous, median, and ulnar nerves of the rat demonstrated by transganglionic transport of choleragenoid-HRP (B-HRP) and wheat germ agglutinin-HRP (WGA-HRP).  |  LaMotte, CC., et al. 1991. J Comp Neurol. 311: 546-62. PMID: 1721924
4. Distribution of lumbar dorsal root fibers in the lower thoracic and lumbosacral spinal cord of the rat studied with choleragenoid horseradish peroxidase conjugate.  |  Rivero-Melián, C. and Grant, G. 1990. J Comp Neurol. 299: 470-81. PMID: 2243162
5. Transganglionic transport of wheat germ agglutinin-HRP and choleragenoid-HRP in rat trigeminal primary sensory neurons.  |  Robertson, B. and Arvidsson, J. 1985. Brain Res. 348: 44-51. PMID: 2415219
6. Inability of choleragenoid-sensitized cells to induce T cell-mediated cytolysis.  |  Forman, J. and Finkelstein, RA. 1977. J Immunol. 118: 1655-8. PMID: 300754
7. The 2.4 A crystal structure of cholera toxin B subunit pentamer: choleragenoid.  |  Zhang, RG., et al. 1995. J Mol Biol. 251: 550-62. PMID: 7658472
8. Simple method for purifying choleragenoid, the natural toxoid of Vibrio cholerae.  |  Mekalanos, JJ., et al. 1977. Infect Immun. 16: 789-95. PMID: 892899
9. Effects of nerve growth factor, brain-derived neurotrophic factor and neurotrophin-3 on the laminar distribution of transganglionically fransported choleragenoid in the spinal cord dorsal horn following transection of the sciatic nerve in the adult rat.  |  Eriksson, NP., et al. 1997. Neuroscience. 78: 863-72. PMID: 9153664
10. Central projections of nerves innervating the rabbit maxillary sinus localized using wheat germ agglutinin-horseradish peroxidase or choleragenoid-horseradish peroxidase.  |  Roche, AK. and Kajander, KC. 1998. J Comp Neurol. 393: 16-24. PMID: 9520097

The preferred Choleragenoid antibody is Choleragenoid Antibody (7901): sc-57682.