Choleragenoid Antibody (7901): sc-57682

Choleragenoid Antibody (7901) is a mouse monoclonal IgG1 antibody that detects the Choleragenoid protein of Vibrio cholerae origin by enzyme-linked immunosorbent assay (ELISA). Anti-Choleragenoid antibody (7901) is available as the non-conjugated isotype antibody. Choleragenoid protein, also known as the B subunit of cholera toxin, plays a crucial role in the pathogenicity of Vibrio cholerae, as Choleragenoid protein facilitates the entry of the A subunit into intestinal epithelial cells. Choleragenoid protein binds specifically to GM1-ganglioside receptors on the surface of these cells, which are essential for the toxin′s action. Binding of Choleragenoid protein to GM1-gangliosides not only directs the enzymatic A subunit to its target but also initiates a cascade of cellular events that lead to severe diarrhea, a hallmark of cholera infection. Understanding the interaction between Choleragenoid protein and GM1-gangliosides is vital for developing therapeutic strategies against cholera, as this interaction highlights potential targets for intervention in the toxin′s mechanism of action. Anti-Choleragenoid antibody (7901) serves as an invaluable tool for researchers studying cholera toxin and its effects on host cells.

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Choleragenoid Antibody (7901) References:

1. Transganglionic transport of choleragenoid by capsaicin-sensitive C-fibre afferents to the substantia gelatinosa of the spinal dorsal horn after peripheral nerve section.  |  Sántha, P. and Jancsó, G. 2003. Neuroscience. 116: 621-7. PMID: 12573705
2. Demonstration of transganglionically transported choleragenoid in rat spinal cord by immunofluorescence cytochemistry.  |  Rivero-Melián, C., et al. 1992. Neurosci Lett. 145: 114-7. PMID: 1281298
3. Brain stem projections of rat lumbar dorsal root ganglia studied with choleragenoid conjugated horseradish peroxidase.  |  Rivero-Melián, C. and Arvidsson, J. 1992. Exp Brain Res. 91: 12-20. PMID: 1301364
4. Choleragenoid horseradish peroxidase used for studying projections of some hindlimb cutaneous nerves and plantar foot afferents to the dorsal horn and Clarke's column in the rat.  |  Rivero-Melián, C. and Grant, G. 1991. Exp Brain Res. 84: 125-32. PMID: 1713167
5. Populations of rat spinal primary afferent neurons with choleragenoid binding compared with those labelled by markers for neurofilament and carbohydrate groups: a quantitative immunocytochemical study.  |  Robertson, B., et al. 1991. J Neurocytol. 20: 387-95. PMID: 1869879
6. Properties of cholera exo-enterotoxin (choleragen) and its natural toxoid (choleragenoid).  |  Finkelstein, RA. 1972. Toxicon. 10: 441-50. PMID: 5071597
7. The 2.4 A crystal structure of cholera toxin B subunit pentamer: choleragenoid.  |  Zhang, RG., et al. 1995. J Mol Biol. 251: 550-62. PMID: 7658472
8. Co-injection of wheat germ agglutinin-HRP and choleragenoid-HRP into the sciatic nerve of the rat blocks transganglionic transport.  |  Liu, H., et al. 1995. J Histochem Cytochem. 43: 489-95. PMID: 7730587
9. Simultaneous demonstration of central projections of different peripheral nerves by anti-choleragenoid immunoglobulin markers.  |  Rivero-Melián, C. 1993. Neuroreport. 4: 743-6. PMID: 8347818
10. Organization of hindlimb nerve projections to the rat spinal cord: a choleragenoid horseradish peroxidase study.  |  Rivero-Melián, C. 1996. J Comp Neurol. 364: 651-63. PMID: 8821452
11. Central projections of nerves innervating the rabbit maxillary sinus localized using wheat germ agglutinin-horseradish peroxidase or choleragenoid-horseradish peroxidase.  |  Roche, AK. and Kajander, KC. 1998. J Comp Neurol. 393: 16-24. PMID: 9520097
12. Retrograde and transganglionic transport of horseradish peroxidase-conjugated cholera toxin B subunit, wheatgerm agglutinin and isolectin B4 from Griffonia simplicifolia I in primary afferent neurons innervating the rat urinary bladder.  |  Wang, HF., et al. 1998. Neuroscience. 87: 275-88. PMID: 9722157

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Choleragenoid Antibody (7901) has 0 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Choleragenoid Antibody (7901) Specifications

Alternate Product Name: Choleragenoid

Product Clone Name: 7901

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: Choleragenoid

Epitope Species: Vibrio cholerae

Product Reactivity/Detection: Choleragenoid

Species Reactivity/Detection: Vibrio cholerae

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: ELISA

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Choleragenoid Antibody (7901): N/A