PA Antibody (C3): sc-52129

PA Antibody (C3) is a mouse monoclonal IgG1 antibody that detects the PA protein of Bacillus anthracis origin by western blotting (WB). Anti-PA antibody (C3) is available as the non-conjugated format, specifically designed for research involving the pathogenic bacterium Bacillus anthracis, which is known for forming spores and producing potent toxins that can lead to severe disease in humans and animals. The protective antigen (PA) plays a crucial role in anthrax toxicity, serving as the binding component that facilitates lethal factor (LF) and edema factor (EF) entry into host cells. Once inside, LF and EF disrupt cellular functions, leading to cell death and edema, respectively. PA extends beyond pathogenesis as a key target for vaccine development, eliciting a strong immune response that can confer protective immunity against anthrax. Large-scale production of recombinant PA is essential for creating effective anthrax vaccines, highlighting PA significance in both disease mechanisms and public health. PA monoclonal antibody (C3) serves as an invaluable tool for researchers studying anthrax toxin interactions and effects, providing insights that could lead to improved therapeutic strategies and vaccine formulations.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

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PA Antibody (C3) References:

1. Protective antigen-mediated antibody response against a heterologous protein produced in vivo by Bacillus anthracis.  |  Brossier, F., et al. 2000. Infect Immun. 68: 5731-4. PMID: 10992478
2. Role of furin in delivery of a CTL epitope of an anthrax toxin-fusion protein.  |  Zhang, Y., et al. 2001. Microbiol Immunol. 45: 119-25. PMID: 11293477
3. Constitutive expression of protective antigen gene of Bacillus anthracis in Escherichia coli.  |  Chauhan, V., et al. 2001. Biochem Biophys Res Commun. 283: 308-15. PMID: 11327699
4. Evaluation of the immune response induced by a nasal anthrax vaccine based on the protective antigen protein in anaesthetized and non-anaesthetized mice.  |  Sloat, BR. and Cui, Z. 2006. J Pharm Pharmacol. 58: 439-47. PMID: 16597361
5. Anthrax lethal toxin has direct and potent inhibitory effects on B cell proliferation and immunoglobulin production.  |  Fang, H., et al. 2006. J Immunol. 176: 6155-61. PMID: 16670324
6. Rapid, sensitive, and specific lateral-flow immunochromatographic device to measure anti-anthrax protective antigen immunoglobulin g in serum and whole blood.  |  Biagini, RE., et al. 2006. Clin Vaccine Immunol. 13: 541-6. PMID: 16682473
7. A monoclonal antibody to Bacillus anthracis protective antigen defines a neutralizing epitope in domain 1.  |  Rivera, J., et al. 2006. Infect Immun. 74: 4149-56. PMID: 16790789
8. Production and characterization of neutralizing monoclonal antibodies that recognize an epitope in domain 2 of Bacillus anthracis protective antigen.  |  Gubbins, MJ., et al. 2006. FEMS Immunol Med Microbiol. 47: 436-43. PMID: 16872381
9. [Anthrax toxins].  |  Brossier, F., et al. 1998. C R Seances Soc Biol Fil. 192: 437-44. PMID: 9759382

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PA Antibody (C3) has 2 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

PA Antibody (C3) Specifications

Alternate Product Name: PA

Product Clone Name: C3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: PA

Epitope Species: Bacillus anthracis

Product Reactivity/Detection: protective antigen of B. anthracis

Species Reactivity/Detection: Bacillus anthracis

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for PA Antibody (C3): N/A