Bordetella pertussis toxin Antibody (20.6): sc-57640

Bordetella pertussis toxin Antibody (20.6) is a mouse monoclonal IgG1 antibody that detects Bordetella pertussis toxin protein of Bordetella pertussis origin by western blotting (WB). Anti-Bordetella pertussis toxin antibody (20.6) is available as the non-conjugated format. Bordetella pertussis toxin plays a crucial role in the pathogenesis of whooping cough, a highly contagious respiratory disease. Bordetella pertussis toxin (20.6) antibody recognizes a protein known for ADP-ribosylating the G protein Gi, which disrupts normal cellular signaling pathways. By preventing adenylate cyclase deactivation, Bordetella pertussis toxin leads to excessive cyclic AMP (cAMP) accumulation within host cells. This increase in cAMP levels results in heightened mucus secretion and impairs various cellular functions, contributing to severe coughing fits characteristic of the disease. The structure of Bordetella pertussis toxin, consisting of five distinct subunits (S1, S2, S3, S4, and S5), is essential for function, as each subunit plays a specific role in toxin activity and host cell interaction. Understanding the structure and function of Bordetella pertussis toxin is vital for developing targeted therapies and vaccines against whooping cough, making anti-Bordetella pertussis toxin antibody (20.6) an invaluable tool for researchers studying this important pathogen.

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Bordetella pertussis toxin Antibody (20.6) References:

1. Comparison of the Bordetella pertussis and Bordetella parapertussis isolates circulating in Saint Petersburg between 1998 and 2000 with Russian vaccine strains.  |  Kourova, N., et al. 2003. J Clin Microbiol. 41: 3706-11. PMID: 12904379
2. Bordetella pertussis acquires resistance to complement-mediated killing in vivo.  |  Pishko, EJ., et al. 2003. Infect Immun. 71: 4936-42. PMID: 12933835
3. Humoral immunity against Bordetella pertussis: antibodies or B cells?  |  Rodriguez, ME. and van der Pol, WL. 2003. Infect Immun. 71: 6686; author reply 6686. PMID: 14573698
4. Comparison of real-time PCR and pyrosequencing for typing Bordetella pertussis toxin subunit 1 variants.  |  Storm, M., et al. 2006. J Microbiol Methods. 65: 153-8. PMID: 16095736
5. Induction of humoral immunity in response to immunization with recombinant Mycobacterium bovis BCG expressing the S1 subunit of Bordetella pertussis toxin.  |  Medeiros, MA., et al. 2005. Can J Microbiol. 51: 1015-20. PMID: 16462859
6. Bordetella pertussis respiratory infection following hematopoietic stem cell transplantation: time for universal vaccination?  |  Florax, A., et al. 2006. Bone Marrow Transplant. 38: 639-40. PMID: 16964268
7. Description of a hybridoma bank towards Bordetella pertussis toxin and surface antigens.  |  Poolman, JT., et al. 1990. Microb Pathog. 8: 377-82. PMID: 1980000
8. Cloning and sequencing of the pertussis toxin genes: operon structure and gene duplication.  |  Nicosia, A., et al. 1986. Proc Natl Acad Sci U S A. 83: 4631-5. PMID: 2873570
9. Multiple species and isoforms of Bordetella pertussis toxin substrates.  |  Brabet, P., et al. 1988. Biochem Biophys Res Commun. 152: 1185-92. PMID: 3132153

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Bordetella pertussis toxin Antibody (20.6) has 0 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Bordetella pertussis toxin Antibody (20.6) Specifications

Alternate Product Name: Bordetella pertussis toxin

Product Clone Name: 20.6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: Bordetella pertussis toxin

Epitope Species: Bordetella pertussis

Product Reactivity/Detection: Bordetella pertussis toxin S1, S3 and S4 subunits

Species Reactivity/Detection: Bordetella pertussis

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB

Vialing Information: Each vial contains 50 µg IgG₁ in 0.5 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Bordetella pertussis toxin Antibody (20.6): N/A