SUC1 Antibody (AA10.2): sc-53445
- SUC1 Antibody (AA10.2) is a mouse monoclonal IgG1 κ SUC1 antibody provided at 200 µg/ml
- raised against p13 from S. Pombe
- SUC1 Antibody (AA10.2) is recommended for detection of SUC1 of S. pombe origin by WB and IP
- Anti-SUC1 Antibody (AA10.2) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for SUC1 Antibody (AA10.2) for WB applications. These reagents are now offered in bundles with SUC1 Antibody (AA10.2) (see ordering information below).
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SUC1 Antibody (AA10.2) is a mouse monoclonal IgG1 kappa light chain antibody that detects SUC1 protein of Schizosaccharomyces pombe origin by western blotting (WB) and immunoprecipitation (IP). SUC1 (AA10.2) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. SUC1, a member of the CKS family, serves as a crucial cyclin-dependent kinase (CDK) subunit, specifically interacting with CDK1 to facilitate the formation of CDK1 complexes essential for cell cycle regulation. SUC1′s function lies in binding to the catalytic subunit of cyclin-dependent kinase (cdc2), which is vital for the progression of both mitotic and meiotic nuclear divisions. In the presence of zinc, SUC1 can form a homodimer, which may influence stability and function. Mutations in SUC1 have been shown to cause significant delays in cell division, and deletion of SUC1 is lethal, resulting in cells that are unable to progress through the cell cycle and exhibit impaired growth. This highlights SUC1′s critical involvement in maintaining cellular proliferation and regulatory role in the complex interactions necessary for cell cycle control.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
SUC1 Antibody (AA10.2) References:
- Role of Suc1 in the activation of the cyclosome by protein kinase Cdk1/cyclin B. | Shteinberg, M. and Hershko, A. 1999. Biochem Biophys Res Commun. 257: 12-8. PMID: 10092502
- Cyclin-dependent kinase and Cks/Suc1 interact with the proteasome in yeast to control proteolysis of M-phase targets. | Kaiser, P., et al. 1999. Genes Dev. 13: 1190-202. PMID: 10323869
- suc1 is an essential gene involved in both the cell cycle and growth in fission yeast. | Hayles, J., et al. 1986. EMBO J. 5: 3373-9. PMID: 16453733
- Mutations at sites involved in Suc1 binding inactivate Cdc2. | Ducommun, B., et al. 1991. Mol Cell Biol. 11: 6177-84. PMID: 1944283
- p13suc1 acts in the fission yeast cell division cycle as a component of the p34cdc2 protein kinase. | Brizuela, L., et al. 1987. EMBO J. 6: 3507-14. PMID: 3322810
- The cell cycle and suc1: from structure to function? | Endicott, JA. and Nurse, P. 1995. Structure. 3: 321-5. PMID: 7613861
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SUC1 Antibody (AA10.2) | sc-53445 | 200 µg/ml | $316.00 | |||
SUC1 Antibody (AA10.2): m-IgG Fc BP-HRP Bundle | sc-526812 | 200 µg Ab; 10 µg BP | $354.00 | |||
SUC1 Antibody (AA10.2): m-IgG1 BP-HRP Bundle | sc-532185 | 200 µg Ab; 20 µg BP | $354.00 | |||
SUC1 Antibody (AA10.2) AC | sc-53445 AC | 500 µg/ml, 25% agarose | $416.00 | |||
SUC1 Antibody (AA10.2) HRP | sc-53445 HRP | 200 µg/ml | $316.00 | |||
SUC1 Antibody (AA10.2) FITC | sc-53445 FITC | 200 µg/ml | $330.00 | |||
SUC1 Antibody (AA10.2) PE | sc-53445 PE | 200 µg/ml | $343.00 | |||
SUC1 Antibody (AA10.2) Alexa Fluor® 488 | sc-53445 AF488 | 200 µg/ml | $357.00 | |||
SUC1 Antibody (AA10.2) Alexa Fluor® 546 | sc-53445 AF546 | 200 µg/ml | $357.00 | |||
SUC1 Antibody (AA10.2) Alexa Fluor® 594 | sc-53445 AF594 | 200 µg/ml | $357.00 | |||
SUC1 Antibody (AA10.2) Alexa Fluor® 647 | sc-53445 AF647 | 200 µg/ml | $357.00 | |||
SUC1 Antibody (AA10.2) Alexa Fluor® 680 | sc-53445 AF680 | 200 µg/ml | $357.00 | |||
SUC1 Antibody (AA10.2) Alexa Fluor® 790 | sc-53445 AF790 | 200 µg/ml | $357.00 |