Shigatoxin Antibody (STX-2): sc-69866
- Shigatoxin Antibody (STX-2) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against Shigatoxin of E. coli origin
- recommended for detection of Shigatoxin by WB
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Shigatoxin Antibody (STX-2). This work is in progress.
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Shigatoxin Antibody (STX-2) is a mouse monoclonal IgG1 antibody that detects Shigatoxin by western blotting (WB). Anti-Shigatoxin antibody (STX-2) plays a crucial role in the study of hemolytic uremic syndrome (HUS), which is the leading cause of acute renal failure in children globally. Shigatoxin, particularly Shigatoxin 2 (Stx2), is produced by enterohemorrhagic Escherichia coli and inhibits protein synthesis in host cells, leading to severe pathological consequences. Shigatoxin′s structure consists of an A subunit and a pentameric B subunit, which facilitates binding to specific receptors on target cell surfaces, such as globotriaosylceramide. This binding enables toxin entry into cells, where Shigatoxin exerts toxic effects, including apoptosis induction and inflammatory cytokine release. Understanding Shigatoxin′s structure is important for developing therapeutic strategies and designing inhibitors that block cellular receptor interactions. Shigatoxin monoclonal antibody (STX-2) serves as an invaluable tool for researchers investigating Stx2-induced cellular damage mechanisms and broader HUS implications.
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Shigatoxin Antibody (STX-2) References:
- Shigatoxin triggers thrombotic thrombocytopenic purpura in genetically susceptible ADAMTS13-deficient mice. | Motto, DG., et al. 2005. J Clin Invest. 115: 2752-61. PMID: 16200209
- Shigatoxin-induced endothelin-1 expression in cultured podocytes autocrinally mediates actin remodeling. | Morigi, M., et al. 2006. Am J Pathol. 169: 1965-75. PMID: 17148661
- Factors affecting survival of Shigatoxin-producing Escherichia coli on abiotic surfaces. | Møretrø, T., et al. 2010. Int J Food Microbiol. 138: 71-7. PMID: 20100628
- Shigatoxin-associated hemolytic uremic syndrome: current molecular mechanisms and future therapies. | Keir, LS., et al. 2012. Drug Des Devel Ther. 6: 195-208. PMID: 22888220
- AAV-mediated expression of an ADAMTS13 variant prevents shigatoxin-induced thrombotic thrombocytopenic purpura. | Jin, SY., et al. 2013. Blood. 121: 3825-9, S1-3. PMID: 23515928
- Direct acute tubular damage contributes to Shigatoxin-mediated kidney failure. | Porubsky, S., et al. 2014. J Pathol. 234: 120-33. PMID: 24909663
- Comparison of Six Chromogenic Agar Media for the Isolation of a Broad Variety of Non-O157 Shigatoxin-Producing Escherichia coli (STEC) Serogroups. | Verhaegen, B., et al. 2015. Int J Environ Res Public Health. 12: 6965-78. PMID: 26090610
- Extrarenal Manifestations in Shigatoxin-associated Haemolytic Uremic Syndrome. | Matthies, J., et al. 2016. Klin Padiatr. 228: 181-8. PMID: 27294341
- Hemolytic Uremic Syndrome Associated With Non-Shigatoxin-producing Infectious Agents: Expanding the Shigatoxin Theory. | Keenswijk, W., et al. 2019. J Pediatr Hematol Oncol. 41: e179-e181. PMID: 29683956
- Adult Shigatoxin-mediated hemolytic uremic syndrome masked by alcohol use and inflammatory bowel disease. | Thompson, R., et al. 2021. BMJ Case Rep. 14: PMID: 34413043
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Shigatoxin Antibody (STX-2) | sc-69866 | 200 µg/ml | $322.00 |