PA Antibody (BAP0104): sc-52126

PA Antibody (BAP0104) is a mouse monoclonal IgG2b antibody that detects protective antigen (PA) of Bacillus anthracis by enzyme-linked immunosorbent assay (ELISA). PA (BAP0104) antibody plays a crucial role in understanding the pathogenic mechanisms of anthrax, as PA is essential for the entry of lethal factor (LF) and edema factor (EF) into host cells. Once PA binds to the target cell, PA facilitates the translocation of these toxic components into the cytosol, where these components exert their detrimental effects. PA′s structure is particularly important because PA forms a heptameric complex that serves as a channel for LF and EF, allowing these factors to penetrate the cell membrane. This structural feature not only underscores PA′s role in anthrax pathogenesis but also highlights PA′s significance as a target for vaccine development, as PA is a major component of anthrax vaccines that confer protective immunity. The ability to produce recombinant PA in large quantities is vital for vaccine efficacy, making anti-PA antibody (BAP0104) an invaluable tool for researchers studying anthrax and developing effective countermeasures against this lethal bacterium.

The preferred PA antibody is PA Antibody (C3): sc-52129.