SEA Antibody (1.B.496): sc-73016

SEA Antibody (1.B.496) is a mouse monoclonal IgG2a antibody that detects Staphylococcus enterotoxin A of Staphylococcus aureus by enzyme-linked immunosorbent assay (ELISA). Anti-Staphylococcus enterotoxin A antibody (1.B.496) plays a crucial role in understanding the pathogenic mechanisms of Staphylococcus aureus, particularly in foodborne illnesses. Staphylococcus enterotoxin A is a potent superantigen that can activate a large number of T cells, leading to an overwhelming immune response characterized by the release of pro-inflammatory cytokines, including interleukin-2. This activation can result in severe clinical manifestations such as high fever, hypotension, and shock, which can be life-threatening. The structure of Staphylococcus enterotoxin A, consisting of a single chain polypeptide with a disulfide bond, is essential for biological activity, enabling effective binding to class II major histocompatibility complex (MHC) molecules and T cell receptors. Understanding the structure-function relationship of Staphylococcus enterotoxin A (1.B.496) is vital for developing therapeutic strategies and interventions to mitigate Staphylococcus aureus infections and food poisoning.

The preferred SEA antibody is SEA Antibody (A108): sc-73345.