SEA Antibody (A108): sc-73345
- SEA Antibody (A108) is a mouse monoclonal IgG2b κ SEA antibody provided at 200 µg/ml
- raised against Staphylococcus aureus Enterotoxin A
- SEA Antibody (A108) is recommended for detection of SEA of Staphylococcus origin by FCM; also recommended for detection of Enterotoxin E
- Anti-SEA Antibody (A108) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG2b BP-HRP are the preferred secondary detection reagents for SEA Antibody (A108). These reagents are now offered in bundles with SEA Antibody (A108) (see ordering information below).
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SEA Antibody (A108) is a mouse monoclonal IgG2b kappa light chain antibody that detects the SEA protein of Staphylococcus origin by flow cytometry (FCM). Anti-SEA antibody (A108) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Staphylococcus enterotoxin A (SEA) is a critical member of the Staphylococcal enterotoxin family, which plays a significant role in foodborne illnesses caused by Staphylococcus aureus. SEA (A108) monoclonal antibody helps study SEA′s ability to activate T cells, leading to the production of interleukin-2, which is essential for T cell proliferation and immune response. This activation occurs through the interaction of SEA with class II major histocompatibility complex (MHC) molecules, facilitating the presentation of the SEA-MHC complex to T cell receptors. The resulting immune response can lead to severe symptoms such as high fever, hypotension, diarrhea, and in extreme cases, shock or death, underscoring the need for effective detection and research tools like SEA (A108) antibody in understanding and combating Staphylococcus-related illnesses.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
SEA Antibody (A108) References:
- Early activation events differentiate the reactivity of two T-cell families to Staphylococcus enterotoxin A. | D'Souza, S., et al. 2003. Cell Immunol. 223: 113-9. PMID: 14527509
- Class II MHC molecules are specific receptors for staphylococcus enterotoxin A. | Mollick, JA., et al. 1989. Science. 244: 817-20. PMID: 2658055
- Mechanism study of the action of Malethamer in staphylococcus enterotoxin-induced diarrhea in monkeys. | Lin, TM., et al. 1967. Arch Int Pharmacodyn Ther. 169: 162-76. PMID: 4964215
- A simple procedure for isolation and purification of A-type staphylococcus enterotoxin. | Ezepchuk, YV., et al. 1981. Acta Microbiol Acad Sci Hung. 28: 25-30. PMID: 6789614
- Anti-HLA class I antibody inhibits Staphylococcus enterotoxin A (SEA)-induced proliferation of human PBMC. | Baskar, P., et al. 1996. Cell Immunol. 172: 135-8. PMID: 8806816
- A mutation of F47 to A in staphylococcus enterotoxin A activates the T-cell receptor Vbeta repertoire in vivo. | Rosendahl, A., et al. 1997. Infect Immun. 65: 5118-24. PMID: 9393804
- Staphylococcus enterotoxin A modulates interleukin 15-induced signaling and mitogenesis in human T cells. | Gerwien, J., et al. 1998. Tissue Antigens. 51: 164-73. PMID: 9510372
- STAPHYLOCOCCUS ENTEROTOXIN: A REVIEW. | DACK, GM. 1963. Jpn J Med Sci Biol. 16: 1-12. PMID: 14044249
- SEROLOGICAL ASSAY OF CULTURE FILTRATES FOR STAPHYLOCOCCUS ENTEROTOXIN. | SILVERMAN, SJ. 1963. J Bacteriol. 85: 955-6. PMID: 14044975
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SEA Antibody (A108) | sc-73345 | 200 µg/ml | $316.00 | |||
SEA Antibody (A108): m-IgG Fc BP-HRP Bundle | sc-525697 | 200 µg Ab; 10 µg BP | $354.00 | |||
SEA Antibody (A108): m-IgG2b BP-HRP Bundle | sc-549625 | 200 µg Ab; 10 µg BP | $354.00 | |||
SEA Antibody (A108) AC | sc-73345 AC | 500 µg/ml, 25% agarose | $416.00 | |||
SEA Antibody (A108) HRP | sc-73345 HRP | 200 µg/ml | $316.00 | |||
SEA Antibody (A108) FITC | sc-73345 FITC | 200 µg/ml | $330.00 | |||
SEA Antibody (A108) PE | sc-73345 PE | 200 µg/ml | $343.00 | |||
SEA Antibody (A108) Alexa Fluor® 488 | sc-73345 AF488 | 200 µg/ml | $357.00 | |||
SEA Antibody (A108) Alexa Fluor® 546 | sc-73345 AF546 | 200 µg/ml | $357.00 | |||
SEA Antibody (A108) Alexa Fluor® 594 | sc-73345 AF594 | 200 µg/ml | $357.00 | |||
SEA Antibody (A108) Alexa Fluor® 647 | sc-73345 AF647 | 200 µg/ml | $357.00 | |||
SEA Antibody (A108) Alexa Fluor® 680 | sc-73345 AF680 | 200 µg/ml | $357.00 | |||
SEA Antibody (A108) Alexa Fluor® 790 | sc-73345 AF790 | 200 µg/ml | $357.00 |