Helicobacter pylori HSP Antibody (6661): sc-65454

Helicobacter pylori HSP Antibody (6661) is a mouse monoclonal IgG2a antibody that detects Helicobacter pylori HSP in Helicobacter pylori by western blotting (WB) and immunofluorescence (IF). Helicobacter pylori HSP plays a crucial role in the bacterium′s ability to survive and thrive in the harsh acidic environment of the stomach, where Helicobacter pylori can lead to conditions such as peptic ulcers and gastritis. Helicobacter pylori HSP functions as a heat shock protein, which is essential for the proper folding and stabilization of other proteins under stress conditions, thereby aiding in the bacterium′s stress response. The presence of Helicobacter pylori HSP is particularly important as Helicobacter pylori HSP helps the bacterium manage the cellular stress induced by the acidic gastric environment and contributes to pathogenicity. By facilitating the correct assembly of proteins, Helicobacter pylori HSP not only supports the bacterium′s survival but also enhances virulence, making Helicobacter pylori HSP a significant target for research and therapeutic interventions.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Helicobacter pylori HSP Antibody (6661) References:

1. Helicobacter pylori and Behçet's disease.  |  Avci, O., et al. 1999. Dermatology. 199: 140-3. PMID: 10559580
2. Helicobacter pylori infection and infertility.  |  Figura, N., et al. 2002. Eur J Gastroenterol Hepatol. 14: 663-9. PMID: 12072601
3. Blockage of HSP 90 modulates Helicobacter pylori-induced IL-8 productions through the inactivation of transcriptional factors of AP-1 and NF-kappaB.  |  Yeo, M., et al. 2004. Biochem Biophys Res Commun. 320: 816-24. PMID: 15240121
4. The Helicobacter pylori cytotoxin CagA is essential for suppressing host heat shock protein expression.  |  Lang, BJ., et al. 2016. Cell Stress Chaperones. 21: 523-33. PMID: 26928021
5. Comparative analysis of the interaction of HSPs in dendritic cells, macrophages, RGM-1 cells infected by Helicobacter pylori.  |  Yao, Y., et al. 2016. Am J Transl Res. 8: 4184-4194. PMID: 27830002
6. The study of H. pylori putative candidate factors for single- and multi-component vaccine development.  |  Mirzaei, N., et al. 2017. Crit Rev Microbiol. 43: 631-650. PMID: 28581361
7. Lessons learnt from the epidemiology of Helicobacter pylori infection in Malaysia: JGHF Marshall and Warren Lecture 2017.  |  Goh, KL. 2018. J Gastroenterol Hepatol. 33: 1177-1184. PMID: 29498759
8. Potential contribution of Helicobacter pylori proteins in the pathogenesis of type 1 gastric neuroendocrine tumor and urticaria. In silico approach.  |  Sánchez Caraballo, A., et al. 2023. PLoS One. 18: e0281485. PMID: 37098080
9. The proteomics analysis of extracellular vesicles revealed the possible function of heat shock protein 60 in Helicobacter pylori infection.  |  Li, Y., et al. 2023. Cancer Cell Int. 23: 272. PMID: 37974232
10. Circulating antibodies to the 60-kD heat shock protein (hsp) family in patients with Helicobacter pylori infection.  |  Barton, SG., et al. 1998. Clin Exp Immunol. 112: 490-4. PMID: 9649220

The preferred Helicobacter pylori HSP antibody is Helicobacter pylori HSP Antibody (BDI586): sc-57780.