Helicobacter pylori HSP Antibody (BDI586): sc-57780

Helicobacter pylori HSP Antibody (BDI586) is a mouse monoclonal IgG2a antibody that detects the Helicobacter pylori HSP protein by western blotting (WB) and immunofluorescence (IF). Anti-Helicobacter pylori HSP antibody (BDI586) is available as a non-conjugated format. The Helicobacter pylori bacterium colonizes the mucus lining of the stomach and duodenum, leading to conditions such as peptic ulcers, gastritis, and duodenitis, affecting approximately 66% of the global population, although many remain asymptomatic. This spiral-shaped Gram-negative bacterium survives in the harsh acidic environment of the stomach, where Helicobacter pylori can be found in various locations, including the mucus layer, attached to epithelial cells, or within vacuoles of epithelial cells. Helicobacter pylori HSPs, or heat shock proteins, play a crucial role in managing cellular stress and assist in the proper folding and functioning of other proteins, which is vital for survival and pathogenicity. HSPs help respond to environmental stressors, ensuring resilience in the hostile gastric environment. By producing adhesins that bind to membrane-associated lipids and carbohydrates, Helicobacter pylori enhances adhesion to epithelial cells, further contributing to persistence and potential disease development.

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Helicobacter pylori HSP Antibody (BDI586) References:

1. ABC of the upper gastrointestinal tract: Epidemiology and diagnosis of Helicobacter pylori infection.  |  Logan, RP. and Walker, MM. 2001. BMJ. 323: 920-2. PMID: 11668141
2. Molecular hydrogen as an energy source for Helicobacter pylori.  |  Olson, JW. and Maier, RJ. 2002. Science. 298: 1788-90. PMID: 12459589
3. Review article: inflammation-related promotion of gastrointestinal carcinogenesis--a perigenetic pathway.  |  Tsuji, S., et al. 2003. Aliment Pharmacol Ther. 18 Suppl 1: 82-9. PMID: 12925144
4. Discovery by Jaworski of Helicobacter pylori and its pathogenetic role in peptic ulcer, gastritis and gastric cancer.  |  Konturek, JW. 2003. J Physiol Pharmacol. 54 Suppl 3: 23-41. PMID: 15075463
5. Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island.  |  Viala, J., et al. 2004. Nat Immunol. 5: 1166-74. PMID: 15489856
6. An endangered species in the stomach.  |  Blaser, MJ. 2005. Sci Am. 292: 38-45. PMID: 15715390
7. Helicobacter pylori duodenal colonization is a strong risk factor for the development of duodenal ulcer.  |  Pietroiusti, A., et al. 2005. Aliment Pharmacol Ther. 21: 909-15. PMID: 15801926
8. Current views of the relationship between Helicobacter pylori and Henoch-Schonlein purpura in children.  |  Xiong, LJ. and Mao, M. 2016. World J Clin Pediatr. 5: 82-8. PMID: 26862506
9. Perspectives from recent advances of Helicobacter pylori vaccines research.  |  Zhang, Y., et al. 2022. Helicobacter. 27: e12926. PMID: 36134470
10. The role of the microbiota in glaucoma.  |  Huang, L., et al. 2023. Mol Aspects Med. 94: 101221. PMID: 37866106
11. Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration.  |  Marshall, BJ. and Warren, JR. 1984. Lancet. 1: 1311-5. PMID: 6145023
12. Ultrastructural localization of urease of Helicobacter pylori.  |  Bode, G., et al. 1993. Med Microbiol Immunol. 182: 233-42. PMID: 8283959

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Helicobacter pylori HSP Antibody (BDI586) has 1 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Helicobacter pylori HSP Antibody (BDI586) Specifications

Alternate Product Name: Helicobacter pylori HSP

Product Clone Name: BDI586

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a

Amino Acids:

Epitope Target: Helicobacter pylori HSP

Epitope Species: Helicobacter pylori

Product Reactivity/Detection: Helicobacter pylori heat shock protein (HSP)

Species Reactivity/Detection: NSR

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IF

Vialing Information: Each vial contains 100 µg IgG_2a in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for Helicobacter pylori HSP Antibody (BDI586): N/A