Staphylococcus aureus Antibody (704): sc-58038

Staphylococcus aureus Antibody (704) is a mouse monoclonal IgG3 antibody that detects Staphylococcus aureus protein through enzyme-linked immunosorbent assay (ELISA). Anti-Staphylococcus aureus antibody (704) is available as a non-conjugated monoclonal isotype antibody. Staphylococcus aureus is a Gram-positive coccus that commonly resides on human skin and in nasal passages, playing a significant role in both commensal and pathogenic interactions. This bacterium produces β-lactamase, an enzyme that degrades the β-lactam ring of penicillin, making Staphylococcus aureus resistant to many antibiotics, including penicillin and cephalosporins. Staphylococcus aureus causes various infections, from minor skin conditions to severe diseases like pneumonia, meningitis, endocarditis, septicemia, and Toxic Shock Syndrome (TSS). The secreted exotoxin Toxic Shock Syndrome Toxin-1 (TSST-1) acts as a key virulence factor by inducing nonspecific binding of major histocompatibility complex (MHC) class II molecules with T cell receptors, leading to widespread T cell activation and immune dysregulation. This dysregulation contributes to various autoimmune and allergic conditions characterized by B cell hyperactivity. TSS symptoms can escalate rapidly, presenting as high fever, hypotension, malaise, and confusion, potentially progressing to severe complications like stupor, coma, and multi-organ failure. Staphylococcus aureus′s ability to evade immune response and cause serious health issues emphasizes the importance of effective detection and monitoring using Staphylococcus aureus monoclonal antibody (704).

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Staphylococcus aureus Antibody (704) References:

1. The changing epidemiology of Staphylococcus aureus?  |  Chambers, HF. 2001. Emerg Infect Dis. 7: 178-82. PMID: 11294701
2. Infection with vancomycin-resistant Staphylococcus aureus containing the vanA resistance gene.  |  Chang, S., et al. 2003. N Engl J Med. 348: 1342-7. PMID: 12672861
3. Prevalence of toxic shock syndrome toxin 1-producing Staphylococcus aureus and the presence of antibodies to this superantigen in menstruating women.  |  Parsonnet, J., et al. 2005. J Clin Microbiol. 43: 4628-34. PMID: 16145118
4. Characterization of T cell receptors engineered for high affinity against toxic shock syndrome toxin-1.  |  Buonpane, RA., et al. 2005. J Mol Biol. 353: 308-21. PMID: 16171815
5. Bacterial superantigen TSST-1 attenuates suppressive efficacy of glucocorticoids and calcineurin inhibitors against blastogenesis of peripheral blood mononuclear cells from patients with antineutrophil cytoplasmic antibody-associated vasculitis and nephrosis.  |  Hirano, T., et al. 2006. Int Immunopharmacol. 6: 924-34. PMID: 16644478
6. Neonatal staphylococcal scalded skin syndrome: massive outbreak due to an unusual phage type.  |  Curran, JP. and Al-Salihi, FL. 1980. Pediatrics. 66: 285-90. PMID: 6447271
7. Differential effects of staphylococcal toxic shock syndrome toxin-1 on B cell apoptosis.  |  Hofer, MF., et al. 1996. Proc Natl Acad Sci U S A. 93: 5425-30. PMID: 8643591
8. The superantigen toxic shock syndrome toxin-1 induces CD40 ligand expression and modulates IgE isotype switching.  |  Jabara, HH. and Geha, RS. 1996. Int Immunol. 8: 1503-10. PMID: 8921429
9. Methicillin-resistant Staphylococcus aureus clinical strain with reduced vancomycin susceptibility.  |  Hiramatsu, K., et al. 1997. J Antimicrob Chemother. 40: 135-6. PMID: 9249217

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Staphylococcus aureus Antibody (704) has 1 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Staphylococcus aureus Antibody (704) Specifications

Alternate Product Name: Staphylococcus aureus

Product Clone Name: 704

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃

Amino Acids:

Epitope Target: Staphylococcus aureus

Epitope Species: Staphylococcus aureus

Product Reactivity/Detection: Staphylococcus aureus, Protein A-negative Staph. aureus and Staph. epidermidis

Species Reactivity/Detection: NSR

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: ELISA

Vialing Information: Each vial contains 100 µg IgG₃ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for Staphylococcus aureus Antibody (704): N/A