LTH-B Antibody (BB2): sc-52064

LTH-B Antibody (BB2) is a mouse monoclonal IgG2b light chain antibody that detects the LTH-B protein of E. coli origin by western blotting (WB). LTH-B, a heat-labile enterotoxin produced by certain strains of Enterotoxigenic E. coli (ETEC), plays a critical role in gastrointestinal pathogenesis, particularly in developing countries where LTH-B is a leading cause of diarrheal disease. This enterotoxin functions by altering the permeability of the intestinal wall, leading to the leakage of water and electrolytes into the intestinal tract, which results in diarrhea. The structural similarity of LTH-B to the Vibrio cholerae enterotoxin (CT) underscores LTH-B′s potential pathogenicity in humans. Notably, LTH-B has the unique ability to penetrate intact skin and activate adaptive immunity, suggesting LTH-B′s potential utility in innovative therapeutic strategies, such as the transcutaneous delivery of tumor antigens for cancer immunotherapy. LTH-B consists of a 103-amino acid precursor, which is distinct from the longer 258-amino acid LTH-A precursor, highlighting the importance of understanding the specific roles and mechanisms of these enterotoxins in disease processes.

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LTH-B Antibody (BB2) References:

1. Binding and hemagglutinating properties of the B subunit(s) of heat-labile enterotoxin isolated from human enterotoxigenic Escherichia coli.  |  Sugii, S. and Tsuji, T. 1990. FEMS Microbiol Lett. 54: 45-50. PMID: 2182380
2. Lymphotoxin-beta receptor expression and its related signaling pathways govern dendritic cell homeostasis and function.  |  De Trez, C. 2012. Immunobiology. 217: 1250-8. PMID: 22795648
3. Cholesterol restricts lymphotoxin β receptor-triggered NF-κB signaling.  |  Banach-Orłowska, M., et al. 2019. Cell Commun Signal. 17: 171. PMID: 31878945
4. A unique amino acid sequence of the B subunit of a heat-labile enterotoxin isolated from a human enterotoxigenic Escherichia coli.  |  Tsuji, T., et al. 1987. Microb Pathog. 2: 381-90. PMID: 3333803
5. Immune mechanisms orchestrate tertiary lymphoid structures in tumors via cancer-associated fibroblasts.  |  Rodriguez, AB., et al. 2021. Cell Rep. 36: 109422. PMID: 34289373
6. Lymphotoxin beta receptor signaling directly controls airway smooth muscle deregulation and asthmatic lung dysfunction.  |  Miki, H., et al. 2023. J Allergy Clin Immunol. 151: 976-990.e5. PMID: 36473503
7. Lymphotoxin-β promotes breast cancer bone metastasis colonization and osteolytic outgrowth.  |  Wang, X., et al. 2024. Nat Cell Biol. 26: 1597-1612. PMID: 39147874
8. Lymphotoxin beta-activated LTBR/NIK/RELB axis drives proliferation in cholangiocarcinoma.  |  Xu, K., et al. 2024. Liver Int. 44: 2950-2963. PMID: 39164890
9. Primary structure of heat-labile enterotoxin produced by Escherichia coli pathogenic for humans.  |  Yamamoto, T., et al. 1984. J Biol Chem. 259: 5037-44. PMID: 6325417
10. Characterization of monoclonal antibodies to heat-labile enterotoxin encoded by a plasmid from a clinical isolate of Escherichia coli.  |  Belisle, BW., et al. 1984. Infect Immun. 43: 1027-32. PMID: 6365779
11. Construction of plasmids useful for production of the B subunit of cholera toxin from Vibrio cholerae or a heat-labile enterotoxin from enterotoxigenic Escherichia coli.  |  Tsuji, T., et al. 1994. Eur J Epidemiol. 10: 393-8. PMID: 7843342
12. A lymphotoxin-beta-specific receptor.  |  Crowe, PD., et al. 1994. Science. 264: 707-10. PMID: 8171323

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-LTH-B Antibody (BB2) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-LTH-B Antibody (BB2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

LTH-B Antibody (BB2) Specifications

Alternate Product Name: LTH-B

Product Clone Name: BB2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b

Amino Acids:

Epitope Target: LTH-B

Epitope Species: E. coli

Product Reactivity/Detection: LTH-B

Species Reactivity/Detection: E. coli

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB

Vialing Information: Each vial contains 100 µg IgG_2b in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for LTH-B Antibody (BB2): N/A