Date published: 2026-4-28

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Mycobacterium tuberculosis RV3134 Dormancy Regulon Antibody (B10): sc-52106

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  • Mycobacterium tuberculosis RV3134 Dormancy Regulon Antibody (B10) is a mouse monoclonal IgG3 provided at 100 µg/ml
  • raised against Mycobaterium tuberculosis RV3134 recombinant protein of dormancy regulon
  • recommended for detection of M. tuberculosis RV3134 dormancy regulon of Mycobacterium tuberculosis origin by WB
  • At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Mycobacterium tuberculosis RV3134 Dormancy Regulon Antibody (B10). This work is in progress.
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    Mycobacterium tuberculosis RV3134 Dormancy Regulon Antibody (B10) is a mouse monoclonal IgG3 antibody that detects RV3134 in Mycobacterium tuberculosis by western blotting (WB). Mycobacterium tuberculosis, the leading cause of tuberculosis, is a Gram-positive obligate anaerobe that can remain dormant within the human host for extended periods, evading the immune response and complicating treatment. RV3134 is a crucial component of the M. tuberculosis dormancy regulon, playing a significant role in the bacterium′s ability to adapt to hostile environments, particularly during periods of low oxygen tension. RV3134 expression is upregulated in response to environmental stressors, which is vital for the pathogen′s survival and persistence in the host. Understanding RV3134 function not only sheds light on the mechanisms of dormancy in M. tuberculosis but also highlights potential targets for therapeutic intervention, as disrupting RV3134 function could render the bacteria more susceptible to treatment. Anti-RV3134 antibody (B10) is an essential tool for researchers studying the dormancy and pathogenicity of this critical human pathogen.

    For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

    Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA

    LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences

    Mycobacterium tuberculosis RV3134 Dormancy Regulon Antibody (B10) References:

    1. DevR-DevS is a bona fide two-component system of Mycobacterium tuberculosis that is hypoxia-responsive in the absence of the DNA-binding domain of DevR.  |  Saini, DK., et al. 2004. Microbiology (Reading). 150: 865-875. PMID: 15073296
    2. Cross talk between DevS sensor kinase homologue, Rv2027c, and DevR response regulator of Mycobacterium tuberculosis.  |  Saini, DK., et al. 2004. FEBS Lett. 565: 75-80. PMID: 15135056
    3. DevS, a heme-containing two-component oxygen sensor of Mycobacterium tuberculosis.  |  Ioanoviciu, A., et al. 2007. Biochemistry. 46: 4250-60. PMID: 17371046
    4. DosT and DevS are oxygen-switched kinases in Mycobacterium tuberculosis.  |  Sousa, EH., et al. 2007. Protein Sci. 16: 1708-19. PMID: 17600145
    5. Interdomain interactions within the two-component heme-based sensor DevS from Mycobacterium tuberculosis.  |  Yukl, ET., et al. 2007. Biochemistry. 46: 9728-36. PMID: 17676768
    6. Rv3134c/devR/devS operon of Mycobacterium bovis BCG is differentially transcribed under 'in vitro' stress conditions.  |  Rodriguez, JG., et al. 2008. Tuberculosis (Edinb). 88: 273-82. PMID: 18243053
    7. Nitric oxide dioxygenation reaction in DevS and the initial response to nitric oxide in Mycobacterium tuberculosis.  |  Yukl, ET., et al. 2011. Biochemistry. 50: 1023-8. PMID: 21250657
    8. A spectroelectrochemical investigation of the heme-based sensor DevS from Mycobacterium tuberculosis: a redox versus oxygen sensor.  |  Barreto, GA., et al. 2019. FEBS J. 286: 4278-4293. PMID: 31254441
    9. Nitric Oxide Signaling for Actinorhodin Production in Streptomyces coelicolor A3(2) via the DevS/R Two-Component System.  |  Honma, S., et al. 2021. Appl Environ Microbiol. 87: e0048021. PMID: 33990302
    10. 'Dissection Educational Videos' (DEVs) and their contribution in anatomy education: a students' perspective.  |  Natsis, K., et al. 2022. Surg Radiol Anat. 44: 33-40. PMID: 34510249

    Ordering Information

    Product NameCatalog #UNITPriceQtyFAVORITES

    Mycobacterium tuberculosis RV3134 Dormancy Regulon Antibody (B10)

    sc-52106
    100 µg/ml
    $322.00