Mycobacterium tuberculosis RV3134 Dormancy Regulon Antibody (G1): sc-52108

Mycobacterium tuberculosis RV3134 Dormancy Regulon Antibody (G1) is a mouse monoclonal IgG1 antibody that detects the Mycobacterium tuberculosis RV3134 Dormancy Regulon protein of Mycobacterium tuberculosis origin by western blotting (WB). Mycobacterium tuberculosis RV3134 Dormancy Regulon (G1) antibody is available as a non-conjugated format. Mycobacterium tuberculosis is the leading cause of tuberculosis and ranks among the most dangerous human pathogens globally. This Gram-positive obligate anaerobe has a slow division rate, taking approximately 15 to 20 hours to replicate, and thrives exclusively within a host organism, allowing dormancy for extended periods without manifesting disease symptoms. RV3134 plays a crucial role in the dormancy regulon of M. tuberculosis, which is essential for survival under hostile conditions, such as low oxygen levels. Understanding RV3134 function is vital, as this knowledge may help elucidate the mechanisms by which M. tuberculosis adapts to environmental stressors, potentially leading to new therapeutic strategies against tuberculosis. RV3134 expression is regulated by various environmental signals, and RV3134 interaction with other proteins in the dormancy regulon, such as Rv2623, highlights the complex network of responses that M. tuberculosis employs to persist in a dormant state.

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Mycobacterium tuberculosis RV3134 Dormancy Regulon Antibody (G1) References:

1. Regulation of the Mycobacterium tuberculosis hypoxic response gene encoding alpha -crystallin.  |  Sherman, DR., et al. 2001. Proc Natl Acad Sci U S A. 98: 7534-9. PMID: 11416222
2. Identification and characterization of mycobacterial proteins differentially expressed under standing and shaking culture conditions, including Rv2623 from a novel class of putative ATP-binding proteins.  |  Florczyk, MA., et al. 2001. Infect Immun. 69: 5777-85. PMID: 11500455
3. Mycobacterium bovis BCG response regulator essential for hypoxic dormancy.  |  Boon, C. and Dick, T. 2002. J Bacteriol. 184: 6760-7. PMID: 12446625
4. Expression of Th1-mediated immunity in mouse lungs induces a Mycobacterium tuberculosis transcription pattern characteristic of nonreplicating persistence.  |  Shi, L., et al. 2003. Proc Natl Acad Sci U S A. 100: 241-6. PMID: 12506197
5. Deletion of two-component regulatory systems increases the virulence of Mycobacterium tuberculosis.  |  Parish, T., et al. 2003. Infect Immun. 71: 1134-40. PMID: 12595424
6. Inhibition of respiration by nitric oxide induces a Mycobacterium tuberculosis dormancy program.  |  Voskuil, MI., et al. 2003. J Exp Med. 198: 705-13. PMID: 12953092
7. High-throughput microplate phosphorylation assays based on DevR-DevS/Rv2027c 2-component signal transduction pathway to screen for novel antitubercular compounds.  |  Saini, DK. and Tyagi, JS. 2005. J Biomol Screen. 10: 215-24. PMID: 15809317
8. Crystallization and preliminary crystallographic analysis of the second GAF domain of DevS from Mycobacterium smegmatis.  |  Cho, HY., et al. 2008. Acta Crystallogr Sect F Struct Biol Cryst Commun. 64: 274-6. PMID: 18391425
9. O2- and NO-sensing mechanism through the DevSR two-component system in Mycobacterium smegmatis.  |  Lee, JM., et al. 2008. J Bacteriol. 190: 6795-804. PMID: 18708494
10. Modeling and simulation of network-on-chip systems with DEVS and DEUS.  |  Amoretti, M. 2014. ScientificWorldJournal. 2014: 982569. PMID: 24895686
11. Light-induced high-efficient cellular production of immune functional extracellular vesicles.  |  Ruan, S., et al. 2022. J Extracell Vesicles. 11: e12194. PMID: 35230743
12. SARS-CoV-2 Spike Protein-Activated Dendritic Cell-Derived Extracellular Vesicles Induce Antiviral Immunity in Mice.  |  Barnwal, A., et al. 2022. ACS Biomater Sci Eng. 8: 5338-5348. PMID: 36445062

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Mycobacterium tuberculosis RV3134 Dormancy Regulon Antibody (G1) has 3 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Mycobacterium tuberculosis RV3134 Dormancy Regulon Antibody (G1) Specifications

Alternate Product Name: Mycobacterium tuberculosis RV3134 Dormancy Regulon

Product Clone Name: G1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: Mycobacterium tuberculosis RV3134 Dormancy Regulon

Epitope Species: Mycobacterium tuberculosis

Product Reactivity/Detection: M. tuberculosis RV3134 dormancy regulon

Species Reactivity/Detection: Mycobacterium tuberculosis

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for Mycobacterium tuberculosis RV3134 Dormancy Regulon Antibody (G1): N/A