Clostridium difficile Toxin A Antibody (5157): sc-58110

Clostridium difficile Toxin A Antibody (5157) is a mouse monoclonal IgG1 antibody that detects Clostridium difficile Toxin A of C. difficile by enzyme-linked immunosorbent assay (ELISA). Clostridium difficile Toxin A (5157) antibody recognizes a protein that plays a critical role in the pathogenesis of antibiotic-associated colitis, as Clostridium difficile Toxin A is one of the two primary toxins released by the bacterium that leads to severe intestinal inflammation and damage. This toxin is composed of 39 repetitive units that facilitate binding to specific carbohydrates on the surface of intestinal epithelial cells, which is crucial for pathogenicity. Once bound, Clostridium difficile Toxin A initiates a cascade of cellular events that result in significant apoptosis of colonocytes, contributing to the formation of ulcers and pseudomembranes. The mechanism involves the activation of p38 MAPK, which subsequently activates p53 and induces p21, leading to the release of cytochrome c and the activation of caspase-3 through Bak. Understanding the structure and function of Clostridium difficile Toxin A is essential for developing therapeutic strategies and diagnostic tools to combat infections caused by this formidable pathogen. Anti-Clostridium difficile Toxin A antibody (5157) serves as an invaluable resource for researchers studying the mechanisms of C. difficile infection and associated diseases.

The preferred Clostridium difficile Toxin A antibody is Clostridium difficile Toxin A Antibody (PCG4): sc-57685.