Choleragenoid Antibody (B8): sc-57683

Choleragenoid Antibody (B8) is a mouse monoclonal IgG1 antibody that detects Choleragenoid of Vibrio cholerae by enzyme-linked immunosorbent assay (ELISA). Choleragenoid, also known as the B subunit of cholera toxin, plays a crucial role in cholera pathogenesis by binding to GM1-ganglioside receptors on intestinal epithelial cell surfaces. This binding facilitates enzymatic A subunit delivery into cells, triggering events that lead to severe fluid loss and diarrhea. Choleragenoid′s pentameric ring structure of B subunits enables multivalent binding to GM1 gangliosides, enhancing toxin penetration through the intestinal barrier. Understanding Choleragenoid′s structural features remains important for developing therapeutic strategies against cholera, highlighting potential intervention targets that could disrupt binding and reduce toxin effects. Anti-Choleragenoid antibody (B8) serves as an invaluable tool for studying cholera toxin interactions and cholera pathogenesis mechanisms.

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Choleragenoid Antibody (B8) References:

1. Transganglionic transport of choleragenoid by capsaicin-sensitive C-fibre afferents to the substantia gelatinosa of the spinal dorsal horn after peripheral nerve section.  |  Sántha, P. and Jancsó, G. 2003. Neuroscience. 116: 621-7. PMID: 12573705
2. Demonstration of transganglionically transported choleragenoid in rat spinal cord by immunofluorescence cytochemistry.  |  Rivero-Melián, C., et al. 1992. Neurosci Lett. 145: 114-7. PMID: 1281298
3. Choleragenoid horseradish peroxidase used for studying projections of some hindlimb cutaneous nerves and plantar foot afferents to the dorsal horn and Clarke's column in the rat.  |  Rivero-Melián, C. and Grant, G. 1991. Exp Brain Res. 84: 125-32. PMID: 1713167
4. Ingenious Action of Vibrio cholerae Neuraminidase Recruiting Additional GM1 Cholera Toxin Receptors for Primary Human Colon Epithelial Cells.  |  Detzner, J., et al. 2022. Microorganisms. 10: PMID: 35744773
5. A new ganglioside showing choleragenoid-binding activity in mouse spleen.  |  Nakamura, K., et al. 1987. J Biochem. 101: 825-35. PMID: 3611042
6. Pathogenesis of experimental cholera. Preparation and isolation of choleragen and choleragenoid.  |  Finkelstein, RA. and LoSpalluto, JJ. 1969. J Exp Med. 130: 185-202. PMID: 4978880
7. Procholeragenoid: an aggregated intermediate in the formation of choleragenoid.  |  Finkelstein, RA., et al. 1971. J Immunol. 107: 1043-51. PMID: 4999257
8. Simultaneous demonstration of central projections of different peripheral nerves by anti-choleragenoid immunoglobulin markers.  |  Rivero-Melián, C. 1993. Neuroreport. 4: 743-6. PMID: 8347818
9. Location, morphology, and central projections of mesencephalic trigeminal neurons innervating rat masticatory muscles studied by axonal transport of choleragenoid-horseradish peroxidase.  |  Raappana, P. and Arvidsson, J. 1993. J Comp Neurol. 328: 103-14. PMID: 8429123
10. Organization of hindlimb nerve projections to the rat spinal cord: a choleragenoid horseradish peroxidase study.  |  Rivero-Melián, C. 1996. J Comp Neurol. 364: 651-63. PMID: 8821452

The preferred Choleragenoid antibody is Choleragenoid Antibody (7901): sc-57682.