Shigella dysenteriae Antibody (0911): sc-58032

Shigella dysenteriae Antibody (0911) is a mouse monoclonal IgG3 kappa light chain antibody that detects the Shigella dysenteriae protein of Shigella dysenteriae origin by western blotting (WB) and immunofluorescence (IF). Anti-Shigella dysenteriae antibody (0911) is available as a non-conjugated format. Shigella dysenteriae is a Gram-negative, non-spore-forming, facultatively anaerobic, non-motile bacterium that is a significant pathogen in the human gastrointestinal tract, known for causing shigellosis, or bacillary dysentery, which can be particularly severe due to the production of Shiga toxin. Shiga toxin is critical for understanding the pathogenicity of Shigella dysenteriae, as Shiga toxin inhibits protein synthesis in host cells, leading to cell death and severe gastrointestinal symptoms. Shiga toxin consists of two subunits: the A subunit, which is responsible for the enzymatic activity that disrupts ribosomal function, and the B subunit, which facilitates the binding of Shiga toxin to specific glycolipids on the surface of host cells, particularly globotriaosylceramide. The interaction between Shiga toxin and host cells underscores the importance of studying Shigella dysenteriae, as this interaction reveals potential therapeutic targets and informs public health strategies to combat the spread of this pathogen, which is primarily transmitted through contaminated food and water.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Shigella dysenteriae Antibody (0911) References:

1. Molecular and phenotypic characterization of potentially new Shigella dysenteriae serotype.  |  Coimbra, RS., et al. 2001. J Clin Microbiol. 39: 618-21. PMID: 11158117
2. [Detection of Shigella dysenteriae in artificially contaminated water with the aid of reaction of increase of phage titer].  |  GOL'DFARB, DM. 1957. Zh Mikrobiol Epidemiol Immunobiol. 28: 26-9. PMID: 13423769
3. Structure of the Shigella dysenteriae 7 O antigen gene cluster and identification of its antigen specific genes.  |  Feng, L., et al. 2004. Microb Pathog. 36: 109-15. PMID: 14687563
4. Release of Shiga toxin by membrane vesicles in Shigella dysenteriae serotype 1 strains and in vitro effects of antimicrobials on toxin production and release.  |  Dutta, S., et al. 2004. Microbiol Immunol. 48: 965-9. PMID: 15611613
5. Synthesis of hexa- to tridecasaccharides related to Shigella dysenteriae type 1 for incorporation in experimental vaccines.  |  Pozsgay, V., et al. 2006. Carbohydr Res. 341: 1408-27. PMID: 16650395
6. Crystal structure of the holotoxin from Shigella dysenteriae at 2.5 A resolution.  |  Fraser, ME., et al. 1994. Nat Struct Biol. 1: 59-64. PMID: 7656009
7. Purification and crystallization of Shiga toxin from Shigella dysenteriae.  |  Kozlov, YV., et al. 1993. J Mol Biol. 232: 704-6. PMID: 8345529
8. Potential virulence of viable but nonculturable Shigella dysenteriae type 1.  |  Rahman, I., et al. 1996. Appl Environ Microbiol. 62: 115-20. PMID: 8572688
9. Towards a vaccine candidate against Shigella dysenteriae 1: expression of the Shiga toxin B-subunit in an attenuated Shigella flexneri aroD carrier strain.  |  Tzschaschel, BD., et al. 1996. Microb Pathog. 21: 277-88. PMID: 8905616

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Shigella dysenteriae Antibody (0911) has 0 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Shigella dysenteriae Antibody (0911) Specifications

Alternate Product Name: Shigella dysenteriae

Product Clone Name: 0911

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃ kappa light chain

Amino Acids:

Epitope Target: Shigella dysenteriae

Epitope Species: Sd

Product Reactivity/Detection: serotype 1

Species Reactivity/Detection: Shigella dysenteriae

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: Shigella dysenteriae

Applications: WB, IF

Vialing Information: Each vial contains 100 µg IgG₃ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Shigella dysenteriae Antibody (0911): N/A