Shigella dysenteriae Inhibitors
Shigella dysenteriae inhibitors operate on a range of cellular mechanisms pivotal for bacterial viability. Ampicillin and Ciprofloxacin act by disrupting structural components. Specifically, Ampicillin targets penicillin-binding proteins to inhibit cell wall synthesis, leading to cell lysis. In contrast, Ciprofloxacin binds to DNA gyrase and topoisomerase IV, impeding DNA supercoiling and replication. Another subset focuses on protein synthesis; Chloramphenicol, Gentamicin, and Tetracycline inhibit the 50S and 30S ribosomal subunits in various ways. For example, Chloramphenicol blocks peptidyl transferase activity, while Gentamicin induces mRNA misreading by binding to the 16S rRNA of the 30S subunit.
The next category of inhibitors interferes with metabolic pathways crucial for DNA synthesis. Sulfamethoxazole and Trimethoprim both target the folic acid synthesis pathway but act on different enzymes: dihydropteroate synthase and dihydrofolate reductase, respectively. This leads to a lack of nucleotide precursors for DNA synthesis. Azithromycin and Rifampin target RNA but through different mechanisms. Azithromycin binds to the 23S rRNA, inhibiting protein synthesis, while Rifampin interferes with RNA polymerase, affecting both RNA synthesis and subsequent protein translation. Lastly, Nalidixic Acid and Fusidic Acid have unique mechanisms: the former targets DNA gyrase, inhibiting DNA supercoiling and replication, while the latter affects the elongation factor G, inhibiting protein synthesis by causing a backlog in the translation machinery.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ampicillin | 69-53-4 | sc-210812 sc-210812A sc-210812B sc-210812C sc-210812D | 100 mg 1 g 5 g 25 g 100 g | $31.00 $101.00 $153.00 $115.00 $408.00 | 11 | |
Targets the penicillin-binding proteins, leading to inhibited cell wall synthesis in Shigella dysenteriae, resulting in cell lysis. | ||||||
Ciprofloxacin | 85721-33-1 | sc-217900 | 1 g | $43.00 | 8 | |
Acts on DNA gyrase and topoisomerase IV, halting DNA supercoiling and re-ligation processes, thereby preventing DNA replication in Shigella dysenteriae. | ||||||
Chloramphenicol | 56-75-7 | sc-3594 | 25 g | $90.00 | 10 | |
Targets the 50S ribosomal subunit, particularly blocking the peptidyl transferase activity, leading to inhibited protein synthesis in Shigella dysenteriae. | ||||||
Gentamicin sulfate | 1405-41-0 | sc-203334 sc-203334A sc-203334F sc-203334B sc-203334C sc-203334D sc-203334E | 1 g 5 g 50 g 100 g 1 kg 2.5 kg 7.5 kg | $56.00 $179.00 $509.00 $725.00 $1836.00 $2652.00 $6248.00 | 3 | |
Binds to the 30S ribosomal subunit, specifically the decoding site on the 16S rRNA, disrupting protein synthesis by inducing misreading of mRNA in Shigella dysenteriae. | ||||||
Tetracycline | 60-54-8 | sc-205858 sc-205858A sc-205858B sc-205858C sc-205858D | 10 g 25 g 100 g 500 g 1 kg | $63.00 $94.00 $270.00 $417.00 $634.00 | 6 | |
Targets the 30S ribosomal subunit, inhibiting the binding of aminoacyl-tRNA to the mRNA-ribosome complex, thereby inhibiting protein synthesis in Shigella dysenteriae. | ||||||
Sulfamethoxazole | 723-46-6 | sc-208405 sc-208405A sc-208405B sc-208405C | 10 g 25 g 50 g 100 g | $37.00 $55.00 $69.00 $109.00 | 5 | |
Inhibits the enzyme dihydropteroate synthase in the folic acid synthesis pathway, resulting in a lack of nucleotide precursors for DNA synthesis in Shigella dysenteriae. | ||||||
Azithromycin | 83905-01-5 | sc-254949 sc-254949A sc-254949B sc-254949C sc-254949D | 25 mg 50 mg 500 mg 1 g 5 g | $52.00 $103.00 $260.00 $364.00 $728.00 | 17 | |
Binds to the 23S rRNA within the 50S ribosomal subunit, preventing the translocation of peptidyl-tRNA from the A site to the P site on the ribosome, leading to inhibited protein synthesis in Shigella dysenteriae. | ||||||
Rifampicin | 13292-46-1 | sc-200910 sc-200910A sc-200910B sc-200910C | 1 g 5 g 100 g 250 g | $97.00 $328.00 $676.00 $1467.00 | 6 | |
Binds to the β subunit of bacterial RNA polymerase, inhibiting RNA synthesis and subsequent protein translation in Shigella dysenteriae. | ||||||
Trimethoprim | 738-70-5 | sc-203302 sc-203302A sc-203302B sc-203302C sc-203302D | 5 g 25 g 250 g 1 kg 5 kg | $67.00 $161.00 $255.00 $721.00 $3401.00 | 4 | |
Inhibits dihydrofolate reductase in the folic acid pathway, leading to a deficit in tetrahydrofolate, a substrate required for nucleotide synthesis, thus impacting DNA synthesis in Shigella dysenteriae. | ||||||
Fusidic acid | 6990-06-3 | sc-215065 | 1 g | $292.00 | ||
Binds to elongation factor G (EF-G) and prevents its release from the ribosome after translocation of peptidyl-tRNA and mRNA, causing a backlog in protein synthesis machinery, leading to the inhibition of protein synthesis in Shigella dysenteriae. | ||||||