Gentamycin Sulfate is a broad-spectrum, aminoglycoside antibiotic used for cell culture which inhibits protein synthesis in sensitive organisms. Gentamicin sulfate inhibits protein synthesis by binding to L6 protein and 50S ribosomal subunit. Gentamicin sulfate is reported to have activity against gram-negative bacteria, Pseudomonas aeruginosa, gram-positive Staphylococcus aureus and some mycoplasmas. Gentamicin sulfate is reported to have low toxicity to mammalian cells and viruses at certain concentrations, and Gentamicin sulfate is useful for long-term tissue culture studies with viruses. This compound is a mixture of Gentamycin c1, c1a and c2.
1. Martin, N.L., et al 1986. Antimicrob. Agents Chemother. 29: 1079-1087. PMID: 2425732
2. Kadurugamuwa, J.L., et al. 1993. J. Bacteriol. 175(: 5798-5805. PMID: 8376327
3. Montenez, J.P., et al. 1994. Toxicol. Lett. 73: 201-208. PMID: 8091428
a mixture of 3 major components, Gentamicin C1, C1a and C2
Soluble in water (115 mg/ml at 25° C), DMSO (<1 mg/ml at 25° C), and ethanol (<1 mg/ml at 25° C).
Store at 4° C
n20D 1.58 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Rated 5 out of
Various publications cite the use of GentamicinVarious publications cite the use of Gentamicin sulfate, a broad-spectrum, aminoglycoside antibiotic, in cell cultures to inhibit protein synthesis in sensitive organisms. -SCBT Publication Review
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