Rifampicin is an antibiotic that potently inhibits RNA polymerase and blocks RNA synthesis in Escherichia coli. The compound has been shown to inhibit α-synuclein fibrillation and disaggregate fibrils in a concentration-dependent manner. Data indicates that Rifampicin can activate the nuclear pregnane X receptor (PXR), which affects cytochrome P450, and the activity of glucuronosyltransferases and P-glycoprotein. Rifampicin has been shown to enhance CYP2C-mediated metabolism, affect compounds that are transported by P-glycoprotein and metabolized by CYP3A4, and has been used in tuberculosis studies.
1. Sundaram, K.S. and Lev, M. 1984. J. Neurochem. 42: 577-581. PMID: 6693888 2. Shukla, G.S., et al. 1991. Biochim. Biophys. Acta. 1083: 101-108. PMID: 1827738 3. Mizrachi, Y., et al. 1996. J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 11: 137-141. PMID: 8556395 4. Cho, J.Y. 2007. Biol. Pharm. Bull. 30: 2105-2112. PMID: 17978484
Soluble in water (pH 4.3) (1.3 mg/ml), chloroform, ethyl acetate, methanol (25 mg/ml), DMSO (25 mg/ml), dimethyl sulfoxide, tetrahydrofuran, and water (pH 7.3) (2.5 mg/ml) at 25° C.
Store at -20° C
~1004.4° C at 760 mmHg (Predicted)
~1.3 g/cm3 (Predicted)
Plasmodium falciparum FCK2 growth as [3H]hypoxanthine uptake after 96 hrs: IC50 = 190 nM; Staphylococcus aureus wild-type RNA polymerase RpoB: IC50 = 15 nM; Escherichia coli RNA polymerase using Kool NC-45 universal RNA polymerase template: IC50 = 11.5 nM
pKa: 8.72, pKb: 7.46
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
I prepared 150 mg/ml stock solution of Rifampin (Rifampicin from MP biomedicals) by using methanol, in this solution it is not 100% dissolved for 150mg/ml. kindly suggest how to prepare 150mg/ml stock and by using which solvent?
Asked by: moni1901
Thank you for your question. Rifampicin is soluble in water (pH 4.3) (1.3 mg/ml), methanol (25 mg/ml), DMSO (25 mg/ml), dimethyl sulfoxide, tetrahydrofuran, and water (pH 7.3) (2.5 mg/ml at 25 °C).
Rated 5 out of
EchchgaddaEchchgadda, et. al. (PubMed ID 17595319) treated primary mouse primary hepatocytes with rifampicin in order to induce PXR recruitment. They found it peaked at 2.5 hours past treatment. -SCBT Publication Review
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