MSP-1 Antibody (PVM-2): sc-52081

MSP-1 Antibody (PVM-2) is a mouse monoclonal IgG2b light chain antibody that detects MSP-1 protein of Plasmodium vivax origin by western blotting (WB). MSP-1, or merozoite surface protein 1, plays a crucial role in the life cycle of the malaria parasite, particularly during blood-stage infection when MSP-1 (PVM-2) monoclonal antibody serves as a major surface component of the merozoite. MSP-1 (PVM-2) antibody is essential for red blood cell invasion, as MSP-1 undergoes selective proteolytic processing and reassembly to facilitate this process. The glycosylphosphatidylinositol (GPI) anchor tethers MSP-1 to the parasite plasma membrane, ensuring proper localization and function. MSP-1 modifications include post-translational glycosylation, with mono- or oligosaccharides linked to serines or threonines, and N-linked carbohydrates associated with asparagines, despite the absence of N-glycosylating machinery in Plasmodium falciparum. These modifications influence MSP-1′s stability, immune recognition, and overall functionality, making anti-MSP-1 antibody (PVM-2) a promising candidate for vaccine development against malaria. MSP-1 (PVM-2) monoclonal antibody serves as an invaluable tool for researchers studying Plasmodium vivax biology and malaria pathogenesis mechanisms.