Staphylococcus aureus TSST-1 Antibody (7915): sc-58196

Staphylococcus aureus TSST-1 Antibody (7915) is a mouse monoclonal IgG2a antibody that detects Toxic Shock Toxin in various applications including enzyme-linked immunosorbent assay (ELISA). Staphylococcus aureus is a Gram-positive bacterium that commonly resides on human skin and in the nasal passages, and produces β-lactamase, which confers resistance to many penicillin and cephalosporin antibiotics. Toxic Shock Syndrome Toxin-1 (TSST-1) produced by this pathogen is a potent exotoxin that plays a critical role in the development of Toxic Shock Syndrome (TSS) by causing non-specific binding of major histocompatibility complex class II molecules with T cell receptors, leading to widespread T cell activation. This mechanism is not only responsible for the acute symptoms of TSS, such as high fever, hypotension, and multi-organ failure, but also contributes to the pathogenesis of various autoimmune and allergic conditions linked to B cell hyperactivity. Furthermore, TSST-1 has been shown to interfere with interleukin-4-induced immunoglobulin E synthesis, highlighting its complex role in immune modulation. Anti-TSST-1 antibody (7915) is an essential tool for researchers studying the mechanisms of TSS and the broader implications of TSST-1 in immune responses.