PA Antibody (BAP0102): sc-52124

PA Antibody (BAP0102) is a mouse monoclonal IgG2b antibody that detects protective antigen (PA) of Bacillus anthracis by enzyme-linked immunosorbent assay (ELISA). Anti-PA antibody (BAP0102) plays a crucial role in understanding the pathogenic mechanisms of anthrax, as PA is essential for the entry of lethal factor (LF) and edema factor (EF) into host cells. Once PA binds to the target cell, PA facilitates the translocation of these toxic components into the cytosol, where these components exert their detrimental effects. PA structure is particularly important because PA forms a heptameric complex that serves as a channel for LF and EF, allowing these toxins to disrupt cellular functions and ultimately lead to cell death. This unique structural feature not only underscores PA significance in anthrax pathogenesis but also highlights PA potential as a target for therapeutic interventions and vaccine development. Furthermore, PA is a key component of anthrax vaccines, as PA induces protective immunity, making PA study vital for public health. Accurate detection and quantification of PA using PA monoclonal antibody (BAP0102) in ELISA assays is essential for both research and clinical applications, particularly in monitoring vaccine efficacy and understanding the dynamics of anthrax infections.

The preferred PA antibody is PA Antibody (C3): sc-52129.