BoNT/E Antibody (BE2): sc-51781

BoNT/E Antibody (BE2) is a mouse monoclonal IgG1 antibody that detects Botulinum neurotoxin type E (BoNT/E) of Clostridium botulinum by western blotting (WB). BoNT/E is a potent neurotoxin that plays a critical role in the pathophysiology of botulism, a serious paralytic illness. Anti-BoNT/E antibody (BE2) functions by cleaving synaptosomal-associated protein 25 (SNAP-25), a key component of the synaptic vesicle fusion machinery, essential for the release of neurotransmitters such as acetylcholine. The cleavage of SNAP-25 by BoNT/E leads to a significant disruption in neurotransmitter release, resulting in flaccid paralysis and other severe neurological symptoms. Understanding the structure of BoNT/E is crucial, as BoNT/E consists of a heavy chain and a light chain connected by a disulfide bond, which facilitates entry into neurons and subsequent enzymatic activity. The heavy chain is responsible for binding to neuronal membranes, while the light chain possesses the proteolytic activity that cleaves SNAP-25. This unique structural arrangement not only underscores the mechanism of action of BoNT/E but also highlights potential as a therapeutic agent in various neurological disorders. BoNT/E monoclonal antibody (BE2) is an invaluable tool for researchers studying the molecular mechanisms of botulism and the neurotoxic effects of Clostridium botulinum.