Verotoxin IIA Antibody (7585): sc-58081

Verotoxin IIA Antibody (7585) is a mouse monoclonal IgG2a antibody that detects Verotoxin IIA in non-species reactive samples by enzyme-linked immunosorbent assay (ELISA). Verotoxin IIA monoclonal antibody (7585) recognizes this potent cytotoxic protein produced by Escherichia coli, which plays a critical role in the pathogenesis of severe gastrointestinal diseases, particularly those associated with hemolytic uremic syndrome. Verotoxin IIA consists of an A subunit, which exerts toxic effects by inhibiting protein synthesis in host cells, and a pentameric B subunit that facilitates binding to specific receptors on the surface of target cells, such as vascular endothelial cells. The interaction of the B subunit with the Gb3 receptor enables cellular entry and leads to ribosome inactivation by the A subunit, resulting in cell death. Understanding the structure and function of Verotoxin IIA is essential for developing therapeutic strategies and diagnostic tools to combat infections caused by pathogenic E. coli strains. Anti-Verotoxin IIA antibody (7585) serves as an invaluable tool for researchers studying toxin action mechanisms and cellular responses to this potent virulence factor.