Yersinia pestis F1 Antibody (YPF19): sc-52303

Yersinia pestis F1 Antibody (YPF19) is a mouse monoclonal IgG1 antibody that detects the Yersinia pestis F1 protein of Yersinia pestis origin by western blotting (WB) and immunofluorescence (IF). Yersinia pestis F1 (YPF19) antibody is available as the non-conjugated anti-Yersinia pestis F1 antibody. The Yersinia pestis F1 protein plays a crucial role in the bacterium′s virulence, as F1 protein is a key component of the protective capsule that helps the pathogen evade the host′s immune response. F1 protein′s ability to inhibit phagocytosis is vital for the survival of Yersinia pestis within the host, allowing Yersinia pestis to persist and cause disease. The presence of F1 protein is particularly important during the infection process, as F1 protein enhances the bacterium′s ability to resist clearance by immune cells, thereby facilitating the establishment of infection. Understanding the function of F1 protein is essential for developing targeted therapies and vaccines against plague, a disease that has historically caused significant mortality.

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Yersinia pestis F1 Antibody (YPF19) References:

1. Small-molecule inhibition of siderophore biosynthesis in Mycobacterium tuberculosis and Yersinia pestis.  |  Ferreras, JA., et al. 2005. Nat Chem Biol. 1: 29-32. PMID: 16407990
2. Flagellin is an effective adjuvant for immunization against lethal respiratory challenge with Yersinia pestis.  |  Honko, AN., et al. 2006. Infect Immun. 74: 1113-20. PMID: 16428759
3. Virulence markers of LCR plasmid in Indian isolates of Yersinia pestis.  |  Khushiramani, R., et al. 2006. APMIS. 114: 15-22. PMID: 16499656
4. Yersinia outer-membrane protein B (YopB): a tool for identification of Yersinia pestis isolates.  |  Khushiramani, R., et al. 2006. J Med Microbiol. 55: 467-469. PMID: 16533997
5. Interaction of Yersinia pestis with macrophages: limitations in YopJ-dependent apoptosis.  |  Zauberman, A., et al. 2006. Infect Immun. 74: 3239-50. PMID: 16714551
6. Gamma interferon, tumor necrosis factor alpha, and nitric oxide synthase 2, key elements of cellular immunity, perform critical protective functions during humoral defense against lethal pulmonary Yersinia pestis infection.  |  Parent, MA., et al. 2006. Infect Immun. 74: 3381-6. PMID: 16714568
7. Efficient tracing of global isolates of Yersinia pestis by restriction fragment length polymorphism analysis using three insertion sequences as probes.  |  Torrea, G., et al. 2006. J Clin Microbiol. 44: 2084-92. PMID: 16757602
8. Characterization of phagosome trafficking and identification of PhoP-regulated genes important for survival of Yersinia pestis in macrophages.  |  Grabenstein, JP., et al. 2006. Infect Immun. 74: 3727-41. PMID: 16790745
9. Yersinia pestis YrbH is a multifunctional protein required for both 3-deoxy-D-manno-oct-2-ulosonic acid biosynthesis and biofilm formation.  |  Tan, L. and Darby, C. 2006. Mol Microbiol. 61: 861-70. PMID: 16817907

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Yersinia pestis F1 Antibody (YPF19) has 1 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Yersinia pestis F1 Antibody (YPF19) Specifications

Alternate Product Name: Yersinia pestis F1

Product Clone Name: YPF19

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: Yersinia pestis F1

Epitope Species: Yersinia pestis

Product Reactivity/Detection: capsule-bearing strains of Y.pestis

Species Reactivity/Detection: Yersinia pestis

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IF

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for Yersinia pestis F1 Antibody (YPF19): N/A