Shigatoxin Antibody (STX-3): sc-69867

Shigatoxin Antibody (STX-3) is a mouse monoclonal IgG1 antibody that detects Shigatoxin by western blotting (WB). Anti-Shigatoxin antibody (STX-3) plays a crucial role in the study of hemolytic uremic syndrome (HUS), which is the leading cause of acute renal failure in children globally. Shigatoxin, particularly Shigatoxin 1 (Stx1), is produced by Shigella dysenteriae type 1 and enterohemorrhagic Escherichia coli, and is known for its ability to disrupt cellular functions in renal epithelial cells. Stx1′s primary function involves increasing arachidonate release and eicosanoid production, which leads to the inhibition of protein synthesis and the promotion of inflammatory cytokine release. This mechanism is particularly important as it contributes to the pathophysiology of HUS, where Stx1 binding to globotriaosylceramide in the brain is associated with neurological complications. Furthermore, Stx1 interaction with proximal tubule cells stimulates the accumulation of IL-6 mRNA, exacerbating the inflammatory response. Understanding Shigatoxin′s role through Shigatoxin monoclonal antibody (STX-3) is essential for developing therapeutic strategies to mitigate Stx1′s effects and associated complications.

The preferred Shigatoxin antibody is Shigatoxin Antibody (STX-1): sc-69865.