Diphtheria Toxin Antibody (7801): sc-58119

Diphtheria Toxin Antibody (7801) is a mouse monoclonal IgG1 antibody that detects Diphtheria toxin with species reactivity specific to Diphtheria toxin by enzyme-linked immunosorbent assay (ELISA). Diphtheria toxin is a potent virulence factor produced by Corynebacterium diphtheriae, which plays a critical role in the pathogenesis of diphtheria by inhibiting protein synthesis in host cells. Anti-Diphtheria toxin antibody (7801) achieves this by catalyzing the ADP-ribosylation and subsequent inactivation of elongation factor 2 (eEF-2), a key protein involved in the translation process. The structure of Diphtheria toxin is particularly important, as Diphtheria toxin consists of a Y-shaped molecule divided into three distinct domains: a catalytic domain (fragment A) that exhibits an α + β fold, a transmembrane domain composed of nine α-helices that facilitate pH-triggered membrane insertion and translocation, and a receptor-binding domain that forms a flattened β-barrel with a jelly-roll-like topology, collectively known as fragment B. Understanding the structural intricacies of Diphtheria toxin is essential for developing therapeutic strategies and vaccines against diphtheria, as these features highlight potential targets for intervention in the toxin′s mechanism of action. Diphtheria toxin monoclonal antibody (7801) serves as an invaluable tool for researchers studying toxin effects and interactions within biological systems.

The preferred Diphtheria Toxin antibody is Diphtheria Toxin Antibody (3B6): sc-51868.