BoNT/E Antibody (KBE42): sc-51784

BoNT/E Antibody (KBE42) is a mouse monoclonal IgG1 antibody that detects Botulinum neurotoxin type E (BoNT/E) of Clostridium botulinum by western blotting (WB). Anti-BoNT/E antibody (KBE42) plays a crucial role in studying the mechanisms of botulism, a serious paralytic illness caused by the potent neurotoxin produced by Clostridium botulinum. BoNT/E functions by cleaving synaptosomal-associated protein 25 (SNAP-25), a key protein involved in the release of acetylcholine at the neuromuscular junction. This cleavage disrupts normal synaptic transmission, leading to flaccid paralysis, which is a hallmark of botulism. Understanding SNAP-25 structure is vital, as multiple domains interact with other proteins in the synaptic vesicle release machinery. The integrity of these interactions is essential for proper neurotransmitter release, and any disruption can significantly impact neuronal communication and muscle function. Using BoNT/E monoclonal antibody (KBE42) in research provides insights into molecular pathways affected by BoNT/E, paving the way for potential therapeutic interventions and a deeper understanding of neuromuscular disorders.