Brucella abortus Antibody (BrH1): sc-66115

Brucella abortus Antibody (BrH1) is a mouse monoclonal IgG2a antibody that detects Brucella abortus with species reactivity specific to Brucella abortus by western blotting (WB). Brucella abortus is a significant pathogen known for causing bovine brucellosis, which can lead to severe reproductive issues in cattle, including spontaneous abortion and infertility. This bacterium primarily infects the placenta and fetus of gestating cows, posing a serious threat to livestock health and agricultural productivity. Moreover, Brucella abortus can be transmitted to humans through the consumption of unpasteurized milk or contact with infected animal discharges, leading to debilitating symptoms such as high fever. A critical aspect of Brucella abortus′s virulence is its ability to utilize cyclic β-1,2-glucan, which aids in hypo-osmotic adaptation, allowing the bacterium to thrive in hostile environments. Additionally, to combat iron deprivation—a common challenge in both natural and host environments—Brucella abortus secretes siderophores like 2,3-dihydroxybenzoic acid and brucebactin, with their regulation being influenced by IRR. Brucella abortus (BrH1) monoclonal antibody serves as an essential tool for researchers studying this pathogen, providing insights into its mechanisms of infection and potential therapeutic targets.

The preferred Brucella abortus antibody is Brucella abortus Antibody (Bx85): sc-51789.