PA Antibody (7821): sc-57952

PA Antibody (7821) is a mouse monoclonal IgG1 antibody that detects protective antigen (PA) of Bacillus anthracis by enzyme-linked immunosorbent assay (ELISA). Anti-PA antibody (7821) plays a crucial role in understanding the pathogenic mechanisms of anthrax, as PA is essential for the entry of lethal factor (LF) and edema factor (EF) into host cells. Once PA binds to the target cell, PA facilitates the translocation of these toxic components into the cytosol, where they exert their detrimental effects. PA structure is particularly important because PA consists of distinct domains that mediate interaction with cell surface receptors, allowing for efficient delivery of LF and EF. This structural characteristic not only underscores PA′s role in anthrax pathogenesis but also highlights PA′s significance as a target for vaccine development, as PA is a major component of anthrax vaccines that confer protective immunity. The ability to produce recombinant PA in large quantities is vital for vaccine efficacy, making PA monoclonal antibody (7821) an invaluable tool for researchers studying anthrax and developing effective therapeutic strategies.

The preferred PA antibody is PA Antibody (C3): sc-52129.