LTH-B Antibody (BG12): sc-52065

LTH-B Antibody (BG12) is a mouse monoclonal IgG1 antibody that detects the LTH-B protein of E. coli origin by western blotting (WB). LTH-B, a heat-labile enterotoxin, plays a critical role in the pathogenesis of enterotoxigenic Escherichia coli (ETEC), which is a significant contributor to diarrheal diseases, particularly in developing countries. This enterotoxin functions by altering the permeability of the intestinal wall, leading to the leakage of water and electrolytes into the intestinal tract, which results in diarrhea. The structural similarity of LTH-B to the Vibrio cholerae enterotoxin (CT) underscores its importance in understanding microbial pathogenesis and developing therapeutic interventions. Notably, LTH-B has the unique ability to penetrate intact skin and activate adaptive immunity, suggesting potential utility in transcutaneous delivery systems for tumor antigens in cancer immunotherapy. The LTH-B protein consists of a 103-amino acid chain precursor, which is distinct from the LTH-A precursor that contains 258 amino acids, highlighting the diversity and specificity of enterotoxins produced by E. coli. Anti-LTH-B antibody (BG12) is an essential tool for researchers studying the mechanisms of enterotoxin action and the development of effective treatments for ETEC-related diseases.

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LTH-B Antibody (BG12) References:

1. Lymphotoxin β receptor signaling promotes development of autoimmune pancreatitis.  |  Seleznik, GM., et al. 2012. Gastroenterology. 143: 1361-1374. PMID: 22863765
2. Lymphotoxin beta receptor signaling limits mucosal damage through driving IL-23 production by epithelial cells.  |  Macho-Fernandez, E., et al. 2015. Mucosal Immunol. 8: 403-13. PMID: 25183367
3. Treg engage lymphotoxin beta receptor for afferent lymphatic transendothelial migration.  |  Brinkman, CC., et al. 2016. Nat Commun. 7: 12021. PMID: 27323847
4. Lymphotoxin β Receptor Controls T Cell Progenitor Entry to the Thymus.  |  Lucas, B., et al. 2016. J Immunol. 197: 2665-72. PMID: 27549174
5. Lymphotoxin-β receptor-NIK signaling induces alternative RELB/NF-κB2 activation to promote metastatic gene expression and cell migration in head and neck cancer.  |  Das, R., et al. 2019. Mol Carcinog. 58: 411-425. PMID: 30488488
6. Host Lymphotoxin-β Receptor Signaling Is Crucial for Angiogenesis of Metanephric Tissue Transplanted into Lymphoid Sites.  |  Francipane, MG., et al. 2020. Am J Pathol. 190: 252-269. PMID: 31585070
7. Lymphotoxin beta receptor is associated with regulation of microRNAs expression and nuclear factor-kappa B activation in lipopolysaccharides (LPS)-stimulated vascular smooth muscle cells.  |  Ling, X., et al. 2020. Ann Palliat Med. 9: 805-815. PMID: 32279515
8. Lymphotoxin-β-receptor (LTβR) signaling on hepatocytes is required for liver regeneration after partial hepatectomy.  |  Sorg, UR., et al. 2021. Biol Chem. 402: 1147-1154. PMID: 34087963
9. Cell circuits between leukemic cells and mesenchymal stem cells block lymphopoiesis by activating lymphotoxin beta receptor signaling.  |  Feng, X., et al. 2023. Elife. 12: PMID: 36912771
10. Lymphotoxin β receptor and tertiary lymphoid organs shape acute and chronic allograft rejection.  |  Zhang, G., et al. 2024. JCI Insight. 9: PMID: 38954463

The preferred LTH-B antibody is LTH-B Antibody (BB2): sc-52064.