SEB Antibody (2B33): sc-73351
- SEB Antibody (2B33) is a mouse monoclonal IgG1 κ SEB antibody, cited in 1 publications, provided at 200 µg/ml
- raised against Staphylococcus aureus enterotoxin B
- SEB Antibody (2B33) is recommended for detection of SEB of Staphylococcus aureus origin by WB and FCM
- Anti-SEB Antibody (2B33) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for SEB Antibody (2B33). This work is in progress.
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SEE ALSO...
SEB Antibody (2B33) is a mouse monoclonal IgG1 kappa light chain antibody that detects the SEB protein of Staphylococcus aureus origin by western blotting (WB) and flow cytometry (FCM). SEB (2B33) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Staphylococcus enterotoxin B (SEB) is a significant member of the Staphylococcal enterotoxin family, which comprises proteins secreted by Staphylococcus aureus that are notorious for causing food poisoning. The clinical implications of SEB are profound, as SEB induces severe symptoms such as high fever, hypotension, diarrhea, shock, and in extreme cases, death. Structurally, SEB is characterized as a single-chain polypeptide that contains a disulfide bond formed by two half cystines, which is crucial for stability and function. This unique structure allows SEB to act as a potent superantigen, effectively activating T cells and stimulating the production and secretion of various cytokines that mediate toxic effects. Furthermore, SEB′s ability to inhibit the activity of naturally occurring regulatory T cells (nTregs) underscores its role in immune dysregulation, making SEB a critical target for research in immunology and infectious diseases.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
SEB Antibody (2B33) References:
- Effect of Staphylococcus enterotoxin B on the concurrent CD8(+) T cell response to influenza virus infection. | Huang, CC., et al. 2000. Cell Immunol. 204: 1-10. PMID: 11006012
- Fos expression in the rat brain after intraperitoneal injection of Staphylococcus enterotoxin B and the effect of vagotomy. | Wang, X., et al. 2004. Neurochem Res. 29: 1667-74. PMID: 15453261
- Immune cell activation and subsequent epithelial dysfunction by Staphylococcus enterotoxin B is attenuated by the green tea polyphenol (-)-epigallocatechin gallate. | Watson, JL., et al. 2005. Cell Immunol. 237: 7-16. PMID: 16213476
- Staphylococcal enterotoxin B inhibits regulatory T cells by inducing glucocorticoid-induced TNF receptor-related protein ligand on monocytes. | Cardona, ID., et al. 2006. J Allergy Clin Immunol. 117: 688-95. PMID: 16522472
- Immunosensing of Staphylococcus enterotoxin B (SEB) in milk with PDMS microfluidic systems using reinforced supported bilayer membranes (r-SBMs). | Dong, Y., et al. 2006. Lab Chip. 6: 675-81. PMID: 16652184
- A possible association of Staphylococcus enterotoxin B-induced asthma and sinusitis. | Liu, T., et al. 2006. J Huazhong Univ Sci Technolog Med Sci. 26: 63-7. PMID: 16711010
- The superantigen Staphylococcus enterotoxin B induces a strong and accelerated secondary T-cell response rather than anergy. | Schultz, H., et al. 1996. Immunology. 87: 49-54. PMID: 8666435
- A receptor-based immunoassay to detect Staphylococcus enterotoxin B in biological fluids. | Mukhin, DN. and Chatterjee, S. 1997. Anal Biochem. 245: 213-7. PMID: 9056214
- In staphylococcus enterotoxin B (SEB)-stimulated human PBMC, the LAK activity of non-T cells might have a major role in the mechanism of glomerular endothelial cells' injury. | Seprényi, G., et al. 1997. Immunobiology. 197: 44-54. PMID: 9241530
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SEB Antibody (2B33) | sc-73351 | 200 µg/ml | $322.00 | |||
SEB Antibody (2B33) AC | sc-73351 AC | 500 µg/ml, 25% agarose | $424.00 | |||
SEB Antibody (2B33) HRP | sc-73351 HRP | 200 µg/ml | $322.00 | |||
SEB Antibody (2B33) FITC | sc-73351 FITC | 200 µg/ml | $336.00 | |||
SEB Antibody (2B33) PE | sc-73351 PE | 200 µg/ml | $349.00 | |||
SEB Antibody (2B33) Alexa Fluor® 488 | sc-73351 AF488 | 200 µg/ml | $364.00 | |||
SEB Antibody (2B33) Alexa Fluor® 546 | sc-73351 AF546 | 200 µg/ml | $364.00 | |||
SEB Antibody (2B33) Alexa Fluor® 594 | sc-73351 AF594 | 200 µg/ml | $364.00 | |||
SEB Antibody (2B33) Alexa Fluor® 647 | sc-73351 AF647 | 200 µg/ml | $364.00 | |||
SEB Antibody (2B33) Alexa Fluor® 680 | sc-73351 AF680 | 200 µg/ml | $364.00 | |||
SEB Antibody (2B33) Alexa Fluor® 790 | sc-73351 AF790 | 200 µg/ml | $364.00 |