PA Antibody (BAP0106): sc-52128

PA Antibody (BAP0106) is a mouse monoclonal IgG1 antibody that detects protective antigen (PA) of Bacillus anthracis by enzyme-linked immunosorbent assay (ELISA). PA (BAP0106) antibody plays a crucial role in understanding the pathogenic mechanisms of anthrax, as PA is essential for the entry of lethal factor (LF) and edema factor (EF) into host cells. Once PA binds to the target cell, PA facilitates the translocation of these toxic components into the cytosol, where these components exert their detrimental effects. PA structure is particularly important because PA contains specific domains that mediate interaction with cell surface receptors, allowing for efficient internalization. This interaction enables the bacterium to hijack host cellular machinery, making PA vital for anthrax lethality. Additionally, PA serves as a key component of anthrax vaccines by eliciting a protective immune response, making PA a target for therapeutic interventions. Producing recombinant PA in large quantities is essential for vaccine development, highlighting PA significance in both research and clinical applications.

The preferred PA antibody is PA Antibody (C3): sc-52129.