CHIPS Antibody (JNC1): sc-52654

CHIPS Antibody (JNC1) is a mouse monoclonal IgG1 antibody that detects CHIPS protein from Staphylococcus aureus by western blotting (WB), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). CHIPS (JNC1) antibody is available in a non-conjugated form, allowing for versatile applications in various experimental settings. The Chemotaxis Inhibiting Protein for Staphylococcus aureus (CHIPS) plays a crucial role in the pathogen′s ability to evade the host immune response by inhibiting the chemotaxis of neutrophils. CHIPS achieves this by blocking the Formyl Peptide Receptor (FPR) and the C5a Receptor on neutrophils, which are essential for directing these immune cells to sites of infection. By interfering with neutrophil recruitment, CHIPS not only aids in the survival of Staphylococcus aureus but also presents a potential target for anti-inflammatory therapies aimed at modulating the immune response during bacterial infections. Understanding CHIPS function is vital, as this highlights the sophisticated mechanisms employed by pathogens to subvert host defenses, paving the way for the development of novel therapeutic strategies.

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CHIPS Antibody (JNC1) References:

1. Chemotaxis inhibitory protein of Staphylococcus aureus, a bacterial antiinflammatory agent.  |  de Haas, CJ., et al. 2004. J Exp Med. 199: 687-95. PMID: 14993252
2. Chemotaxis inhibitory protein of Staphylococcus aureus binds specifically to the C5a and formylated peptide receptor.  |  Postma, B., et al. 2004. J Immunol. 172: 6994-7001. PMID: 15153520
3. Complete genomes of two clinical Staphylococcus aureus strains: evidence for the rapid evolution of virulence and drug resistance.  |  Holden, MT., et al. 2004. Proc Natl Acad Sci U S A. 101: 9786-91. PMID: 15213324
4. N-terminal residues of the chemotaxis inhibitory protein of Staphylococcus aureus are essential for blocking formylated peptide receptor but not C5a receptor.  |  Haas, PJ., et al. 2004. J Immunol. 173: 5704-11. PMID: 15494522
5. The structure of the C5a receptor-blocking domain of chemotaxis inhibitory protein of Staphylococcus aureus is related to a group of immune evasive molecules.  |  Haas, PJ., et al. 2005. J Mol Biol. 353: 859-72. PMID: 16213522
6. Neutrophil chemotaxis by pathogen-associated molecular patterns--formylated peptides are crucial but not the sole neutrophil attractants produced by Staphylococcus aureus.  |  Dürr, MC., et al. 2006. Cell Microbiol. 8: 207-17. PMID: 16441432
7. The innate immune modulators staphylococcal complement inhibitor and chemotaxis inhibitory protein of Staphylococcus aureus are located on beta-hemolysin-converting bacteriophages.  |  van Wamel, WJ., et al. 2006. J Bacteriol. 188: 1310-5. PMID: 16452413
8. Early expression of SCIN and CHIPS drives instant immune evasion by Staphylococcus aureus.  |  Rooijakkers, SH., et al. 2006. Cell Microbiol. 8: 1282-93. PMID: 16882032
9. Extensive phage dynamics in Staphylococcus aureus contributes to adaptation to the human host during infection.  |  Goerke, C., et al. 2006. Mol Microbiol. 61: 1673-85. PMID: 16968231

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CHIPS Antibody (JNC1) has 0 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CHIPS Antibody (JNC1) Specifications

Alternate Product Name: CHIPS

Product Clone Name: JNC1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: CHIPS

Epitope Species: Staphylococcus aureus

Product Reactivity/Detection: CHIPS

Species Reactivity/Detection: S. aureus

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IF, IHC(P), FCM

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for CHIPS Antibody (JNC1): N/A