LF Antibody (BAL0105): sc-52054

LF Antibody (BAL0105) is a mouse monoclonal IgG1 antibody that detects the LF protein of Bacillus anthracis origin by enzyme-linked immunosorbent assay (ELISA). LF (BAL0105) antibody is available as the non-conjugated form. LF protein, or lethal factor, is a critical component of the anthrax toxin, which plays a significant role in the pathogenesis of Bacillus anthracis infections. Once internalized into host cells, lethal factor acts as a metalloprotease that disrupts cellular signaling pathways, leading to cell death and contributing to the severe symptoms associated with anthrax. This mechanism of action allows the bacterium to evade the host′s immune response, making lethal factor a target for therapeutic interventions and vaccine development. Lethal factor, along with protective antigen and edema factor, forms the basis of the anthrax toxin, which is responsible for the disease′s lethality. Understanding lethal factor′s function is crucial for developing effective treatments and preventive measures against anthrax, highlighting anti-LF antibody (BAL0105)′s importance in research and diagnostic applications.

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LF Antibody (BAL0105) References:

1. Protective antigen-mediated antibody response against a heterologous protein produced in vivo by Bacillus anthracis.  |  Brossier, F., et al. 2000. Infect Immun. 68: 5731-4. PMID: 10992478
2. Role of furin in delivery of a CTL epitope of an anthrax toxin-fusion protein.  |  Zhang, Y., et al. 2001. Microbiol Immunol. 45: 119-25. PMID: 11293477
3. Genetic, physical, and transcript map of the Ltxs1 region of mouse chromosome 11.  |  Watters, JW. and Dietrich, WF. 2001. Genomics. 73: 223-31. PMID: 11318612
4. Constitutive expression of protective antigen gene of Bacillus anthracis in Escherichia coli.  |  Chauhan, V., et al. 2001. Biochem Biophys Res Commun. 283: 308-15. PMID: 11327699
5. Detection of anthrax toxin in the serum of animals infected with Bacillus anthracis by using engineered immunoassays.  |  Mabry, R., et al. 2006. Clin Vaccine Immunol. 13: 671-7. PMID: 16760326
6. Single-step purification of recombinant anthrax lethal factor from periplasm of Escherichia coli.  |  Chang, HH., et al. 2006. J Biotechnol. 126: 277-85. PMID: 16797097
7. Selectively guanidinylated derivatives of neamine. Syntheses and inhibition of anthrax lethal factor protease.  |  Jiao, GS., et al. 2006. Bioorg Med Chem Lett. 16: 5183-9. PMID: 16870442
8. Proteomic analyses of murine macrophages treated with Bacillus anthracis lethal toxin.  |  Sapra, R., et al. 2006. Microb Pathog. 41: 157-67. PMID: 16950595
9. [Anthrax toxins].  |  Brossier, F., et al. 1998. C R Seances Soc Biol Fil. 192: 437-44. PMID: 9759382

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-LF Antibody (BAL0105) has 0 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

LF Antibody (BAL0105) Specifications

Alternate Product Name: LF

Product Clone Name: BAL0105

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: LF

Epitope Species: Bacillus anthracis

Product Reactivity/Detection: lethal factor antigen

Species Reactivity/Detection: Bacillus anthracis

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: ELISA

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for LF Antibody (BAL0105): N/A