SEG Antibody (SEG-16): sc-66138

SEG Antibody (SEG-16) is a mouse monoclonal IgG2a antibody that detects the SEG protein of Staphylococcus aureus origin by western blotting (WB). Anti-SEG antibody (SEG-16) is available as a non-conjugated monoclonal isotype antibody. The SEG protein, or Staphylococcal Enterotoxin G, is a 233 amino acid enterotoxin that plays a critical role in the pathogenicity of Staphylococcus aureus, a notorious human pathogen. This enterotoxin is secreted into the intestine and is known for its ability to induce severe gastrointestinal symptoms, including nausea, vomiting, and diarrhea, which are characteristic of Staphylococcal food poisoning. One of the key aspects of SEG′s function is its ability to act as a superantigen, which allows SEG to bind to T-cell receptors and major histocompatibility complex (MHC) proteins without being internalized and processed by the host cell. This unique mechanism not only triggers a robust immune response but also leads to an uncontrolled activation of T-cells, resulting in a cytokine storm that can have severe consequences for the host. The ability of SEG to resist degradation and maintain activity in the gastrointestinal tract underscores SEG′s significance as a virulence factor in Staphylococcus aureus infections, making SEG antibody (SEG-16) an essential tool for researchers studying the mechanisms of enterotoxin-induced pathogenesis and immune evasion.

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SEG Antibody (SEG-16) References:

1. Exotoxins of Staphylococcus aureus.  |  Dinges, MM., et al. 2000. Clin Microbiol Rev. 13: 16-34, table of contents. PMID: 10627489
2. Staphylococcal enterotoxins.  |  Balaban, N. and Rasooly, A. 2000. Int J Food Microbiol. 61: 1-10. PMID: 11028954
3. Detection of seg, seh, and sei genes in Staphylococcus aureus isolates and determination of the enterotoxin productivities of S. aureus isolates Harboring seg, seh, or sei genes.  |  Omoe, K., et al. 2002. J Clin Microbiol. 40: 857-62. PMID: 11880405
4. Staphylococcus aureus and food poisoning.  |  Le Loir, Y., et al. 2003. Genet Mol Res. 2: 63-76. PMID: 12917803
5. Simultaneous analysis of multiple staphylococcal enterotoxin genes by an oligonucleotide microarray assay.  |  Sergeev, N., et al. 2004. J Clin Microbiol. 42: 2134-43. PMID: 15131181
6. Pattern of enterotoxin genes seg, seh, sei and sej positive Staphylococcus aureus isolated from bovine mastitis.  |  Zschöck, M., et al. 2005. Vet Microbiol. 108: 243-9. PMID: 15916869
7. Detection of enterotoxin genes seg, seh, sei, and sej and of a novel aroA genotype in Jordanian clinical isolates of Staphylococcus aureus.  |  El-Huneidi, W., et al. 2006. Diagn Microbiol Infect Dis. 56: 127-32. PMID: 16725300
8. Diversity in Staphylococcus aureus enterotoxins.  |  Thomas, D., et al. 2007. Chem Immunol Allergy. 93: 24-41. PMID: 17369698
9. Staphylococcal enterotoxins G and I, a cause of severe but reversible neonatal enteropathy.  |  Naik, S., et al. 2008. Clin Gastroenterol Hepatol. 6: 251-4. PMID: 18063418
10. Superantigens: mechanism of T-cell stimulation and role in immune responses.  |  Herman, A., et al. 1991. Annu Rev Immunol. 9: 745-72. PMID: 1832875
11. Food poisoning and Staphylococcus aureus enterotoxins.  |  Argudín, MÁ., et al. 2010. Toxins (Basel). 2: 1751-73. PMID: 22069659
12. Superantigens and their potential role in human disease.  |  Kotzin, BL., et al. 1993. Adv Immunol. 54: 99-166. PMID: 8397479