CS protein Antibody (PVC-1): sc-51854

CS protein Antibody (PVC-1) is a mouse monoclonal IgG1 antibody that detects CS protein of Plasmodium vivax origin by western blotting (WB). Anti-CS protein antibody (PVC-1) is available as non-conjugated format. The circumsporozoite (CS) protein plays a crucial role in malaria parasite life cycles, specifically during the sporozoite stage, which infects vertebrate hosts. CS protein is located on sporozoite surfaces, facilitating migration to mosquito vector salivary glands and subsequently to mammalian host livers. CS protein mediates these critical steps in parasite life cycles, proving essential for successful malaria transmission. CS protein levels indicate development of inner membranes and associated microtubules beneath oocyst outer membranes, which are vital for sporozoite budding processes. Understanding CS protein function and location aids in studying malaria transmission while providing insights into potential vaccine development and therapeutic intervention targets against malaria.

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CS protein Antibody (PVC-1) References:

1. Levels of circumsporozoite protein in the Plasmodium oocyst determine sporozoite morphology.  |  Thathy, V., et al. 2002. EMBO J. 21: 1586-96. PMID: 11927543
2. The basolateral domain of the hepatocyte plasma membrane bears receptors for the circumsporozoite protein of Plasmodium falciparum sporozoites.  |  Cerami, C., et al. 1992. Cell. 70: 1021-33. PMID: 1326407
3. Circumsporozoite protein genes of malaria parasites (Plasmodium spp.): evidence for positive selection on immunogenic regions.  |  Hughes, AL. 1991. Genetics. 127: 345-53. PMID: 1706291
4. Multiple display of foreign peptides on a filamentous bacteriophage. Peptides from Plasmodium falciparum circumsporozoite protein as antigens.  |  Greenwood, J., et al. 1991. J Mol Biol. 220: 821-7. PMID: 1880799
5. Cloned cytotoxic T cells recognize an epitope in the circumsporozoite protein and protect against malaria.  |  Romero, P., et al. 1989. Nature. 341: 323-6. PMID: 2477703
6. Protection against malaria by immunization with plasmid DNA encoding circumsporozoite protein.  |  Sedegah, M., et al. 1994. Proc Natl Acad Sci U S A. 91: 9866-70. PMID: 7937907
7. Circumsporozoite protein is required for development of malaria sporozoites in mosquitoes.  |  Ménard, R., et al. 1997. Nature. 385: 336-40. PMID: 9002517