Bordetella pertussis toxin subunit S3 Antibody (21.3D11): sc-57641

Bordetella pertussis toxin subunit S3 Antibody (21.3D11) is a mouse monoclonal IgG1 antibody that detects Bordetella pertussis toxin subunit S3 by western blotting (WB). Bordetella pertussis is a Gram-negative, non-motile coccobacillus and the causative agent of whooping cough, a highly contagious respiratory disease marked by severe coughing fits. Bordetella pertussis toxin, particularly the S3 subunit, plays a crucial role in the bacterium′s virulence by facilitating the covalent modification of GTP-binding Gi proteins through ADP-ribosylation. This modification inhibits the normal deactivation of adenylate cyclase, leading to an excessive accumulation of cyclic AMP (cAMP) within host cells. The elevated cAMP levels disrupt various cellular functions, resulting in increased mucus production and contributing to the characteristic symptoms of whooping cough. The S3 subunit, along with the other components of the pertussis toxin, is essential for the toxin′s overall structure and function, making S3 a significant target for both research and therapeutic applications. Bordetella pertussis toxin subunit S3 (21.3D11) monoclonal antibody serves as an invaluable tool for studying the pathogenic mechanisms of Bordetella pertussis and for developing strategies to combat this infectious disease.

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Bordetella pertussis toxin subunit S3 Antibody (21.3D11) References:

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