SEC Antibody (C165): sc-73353
- SEC Antibody (C165) is a mouse monoclonal IgG1 κ SEC antibody provided at 200 µg/ml
- raised against Staphylococcus aureus enterotoxin C
- SEC Antibody (C165) is recommended for detection of Enterotoxin C of Staphylococcus aureus origin by FCM
- Anti-SEC Antibody (C165) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for SEC Antibody (C165). These reagents are now offered in bundles with SEC Antibody (C165) (see ordering information below).
SEC Antibody (C165) is a mouse monoclonal IgG1 kappa light chain antibody that detects the SEC protein of Staphylococcus aureus origin by flow cytometry (FCM). Anti-SEC antibody (C165) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The SEC protein, or Staphylococcal Enterotoxin C, is a potent superantigen that plays a critical role in the immune response by stimulating non-specific T-cell proliferation. This characteristic makes SEC not only a significant factor in the pathogenesis of diseases such as toxic shock syndrome and bovine mastitis but also a promising candidate for cancer immunotherapy, as SEC can induce apoptosis in tumor cells. The structure of SEC is particularly important, as SEC consists of a single chain polypeptide with a unique disulfide bond formed by two half cysteines, which is essential for biological activity and stability. Additionally, SEC is predominantly produced by methicillin-resistant strains of Staphylococcus aureus, highlighting SEC′s relevance in both clinical and therapeutic contexts.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
SEC Antibody (C165) References:
- Suitability of a recombinant Staphylococcus aureus enterotoxin C bovine variant for immunodiagnostics and therapeutic vaccine development. | de Carvalho Uhl, MV., et al. 2004. Vaccine. 22: 4191-202. PMID: 15474709
- A mutant of staphylococcal enterotoxin C devoid of bacterial superantigenic activity elicits a Th2 immune response for protection against Staphylococcus aureus infection. | Hu, DL., et al. 2005. Infect Immun. 73: 174-80. PMID: 15618152
- Purpura fulminans due to Staphylococcus aureus. | Kravitz, GR., et al. 2005. Clin Infect Dis. 40: 941-7. PMID: 15824983
- Conjugates of group A and W135 capsular polysaccharides of neisseria meningitidis bound to recombinant Staphylococcus aureus enterotoxin C1: preparation, physicochemical characterization, and immunological properties in mice. | Jin, Z., et al. 2005. Infect Immun. 73: 7887-93. PMID: 16299279
- Development of serum IgM antibodies against superantigens of Staphylococcus aureus and Streptococcus pyogenes in Kawasaki disease. | Matsubara, K., et al. 2006. Clin Exp Immunol. 143: 427-34. PMID: 16487241
- [Detection of the genes of pyrogenic toxins of superantigens in clinical isolates of methicillin resistant Staphylococcus aureus]. | Dmitrenko, OA., et al. 2006. Zh Mikrobiol Epidemiol Immunobiol. 36-42. PMID: 16758896
- Unique features of bovine lymphocytes exposed to a staphylococcal enterotoxin. | Park, YH., et al. 2006. J Vet Sci. 7: 233-9. PMID: 16871017
- Expression and bioactivity analysis of Staphylococcal enterotoxin M and N. | Pan, YQ., et al. 2007. Protein Expr Purif. 56: 286-92. PMID: 17910920
- The pilot study of anti-tumor effects versus immunosuppression of Staphylococcal Enterotoxin C. | Jie, KG., et al. 2007. Cancer Biol Ther. 6: 1584-91. PMID: 17912027
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SEC Antibody (C165) | sc-73353 | 200 µg/ml | $316.00 | |||
SEC Antibody (C165): m-IgG Fc BP-HRP Bundle | sc-527003 | 200 µg Ab; 10 µg BP | $354.00 | |||
SEC Antibody (C165): m-IgG1 BP-HRP Bundle | sc-532376 | 200 µg Ab; 20 µg BP | $354.00 | |||
SEC Antibody (C165) AC | sc-73353 AC | 500 µg/ml, 25% agarose | $416.00 | |||
SEC Antibody (C165) HRP | sc-73353 HRP | 200 µg/ml | $316.00 | |||
SEC Antibody (C165) FITC | sc-73353 FITC | 200 µg/ml | $330.00 | |||
SEC Antibody (C165) PE | sc-73353 PE | 200 µg/ml | $343.00 | |||
SEC Antibody (C165) Alexa Fluor® 488 | sc-73353 AF488 | 200 µg/ml | $357.00 | |||
SEC Antibody (C165) Alexa Fluor® 546 | sc-73353 AF546 | 200 µg/ml | $357.00 | |||
SEC Antibody (C165) Alexa Fluor® 594 | sc-73353 AF594 | 200 µg/ml | $357.00 | |||
SEC Antibody (C165) Alexa Fluor® 647 | sc-73353 AF647 | 200 µg/ml | $357.00 | |||
SEC Antibody (C165) Alexa Fluor® 680 | sc-73353 AF680 | 200 µg/ml | $357.00 | |||
SEC Antibody (C165) Alexa Fluor® 790 | sc-73353 AF790 | 200 µg/ml | $357.00 |