GGPL-III Antibody (LIII-63): sc-13571

GGPL-III Antibody (LIII-63) is a mouse monoclonal IgM antibody that detects the GGPL-III protein of Mycoplasma fermentans origin by enzyme-linked immunosorbent assay (ELISA). Anti-GGPL-III antibody (LIII-63) is available as the non-conjugated format. GGPL-III protein plays a crucial role in the unique choline metabolic pathway of Mycoplasma fermentans, which is responsible for generating phosphocholine-containing glycoglycerolipids, including 6′-O-phosphocholine-alpha-glucopyranosyl-(1′-3)-1,2-diacyl-sn-glycerol (GGPL-I) and 1′-phosphocholine,2′-amino dihydroxypropane-3′-phospho-6′-alpha-glucopyranosyl-(1′-3)-1,2-diacyl-glycerol (GGPL-III). This metabolic pathway contributes to Mycoplasma fermentans′ ability to adapt and thrive in various environments, including human mucosal tissues, where Mycoplasma fermentans is found in approximately 45% of healthy adults. GGPL-III presence is particularly noteworthy in human health, as antibodies to GGPL-III appear significantly elevated in sera of individuals infected with HIV-1 compared to healthy donors, suggesting a potential role of Mycoplasma fermentans in the pathogenesis of acquired immunodeficiency syndrome (AIDS). These findings highlight GGPL-III significance in microbial metabolism and human disease, making GGPL-III monoclonal antibody (LIII-63) valuable for research and diagnostic applications.

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GGPL-III Antibody (LIII-63) References:

1. Monoclonal antibody against Mycoplasma fermentans-specific aminoglycoglycerolipid.  |  Matsuda, K., et al. 2000. Microbiol Immunol. 44: 695-702. PMID: 11021400
2. Mycoplasma fermentans glycolipid-antigen as a pathogen of rheumatoid arthritis.  |  Kawahito, Y., et al. 2008. Biochem Biophys Res Commun. 369: 561-6. PMID: 18307980
3. Variation of genes encoding GGPLs syntheses among Mycoplasma fermentans strains.  |  Fujihara, M., et al. 2010. J Vet Med Sci. 72: 805-8. PMID: 20134120
4. Enzymatic synthesis of Mycoplasma fermentans specific glycoglycerophospholipid from 1,2-dipalmitoylglycerol.  |  Ishida, N., et al. 2010. J Biosci Bioeng. 109: 341-5. PMID: 20226374
5. Promotion of arthritis and allergy in mice by aminoglycoglycerophospholipid, a membrane antigen specific to Mycoplasma fermentans.  |  Sato, N., et al. 2010. FEMS Immunol Med Microbiol. 59: 33-41. PMID: 20236320
6. An easy α-glycosylation methodology for the synthesis and stereochemistry of mycoplasma α-glycolipid antigens.  |  Nishida, Y., et al. 2012. Beilstein J Org Chem. 8: 629-39. PMID: 22563361
7. Identification of phosphocholine-containing glycoglycerolipids purified from Mycoplasma fermentans-infected human helper T-cell culture as components of M. fermentans.  |  Matsuda, K., et al. 1995. Microbiol Immunol. 39: 307-13. PMID: 7565170
8. Phosphocholine-containing glycoglycerolipids (GGPL-I and GGPL-III) are species-specific major immunodeterminants of Mycoplasma fermentans.  |  Matsuda, K., et al. 1997. Biochem Biophys Res Commun. 233: 644-9. PMID: 9168906
9. Structure of a novel phosphocholine-containing aminoglycoglycerolipid of Mycoplasma fermentans.  |  Matsuda, K., et al. 1997. Biochim Biophys Acta. 1349: 1-12. PMID: 9421191
10. Detection of serum antibodies against phosphocholine-containing aminoglycoglycerolipid specific to Mycoplasma fermentans in HIV-1 infected individuals.  |  Li, JL., et al. 1997. J Immunol Methods. 208: 103-13. PMID: 9433466

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-GGPL-III Antibody (LIII-63) has 0 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

GGPL-III Antibody (LIII-63) Specifications

Alternate Product Name: GGPL-III

Product Clone Name: LIII-63

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids:

Epitope Target: GGPL-III

Epitope Species: Mycoplasma fermentans

Product Reactivity/Detection: GGPL-III

Species Reactivity/Detection: Mycoplasma fermentans

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for GGPL-III Antibody (LIII-63): N/A