BoNT/D Antibody (KB21): sc-51778

BoNT/D Antibody (KB21) is a mouse monoclonal IgG1 antibody that detects BoNT/D of Clostridium botulinum by immunofluorescence (IF). BoNT/D, or botulinum neurotoxin type D, is a potent neurotoxin produced by the anaerobic bacterium Clostridium botulinum and plays a critical role in the pathogenesis of botulism, a severe paralytic illness. The structure of BoNT/D consists of a heavy chain and a light chain linked by a disulfide bond, which is essential for function. The heavy chain facilitates binding to neuronal cells, while the light chain possesses enzymatic activity that cleaves specific proteins involved in neurotransmitter release. This unique structural arrangement allows BoNT/D to effectively inhibit acetylcholine release at the neuromuscular junction, leading to flaccid paralysis. The ability of BoNT/D to disrupt synaptic transmission underscores significance not only in clinical settings but also in research applications, where understanding mechanism can aid in developing therapeutic strategies against neuromuscular disorders. Anti-BoNT/D antibody (KB21) serves as an invaluable tool for researchers studying neurotoxin effects and interactions within the nervous system.